Study on the Injectable Magnesium-calcium Phosphate Cements

doi:10.15541/jim20130625

Abstract

Abstract:

Injectable magnesium-calcium phosphate cements (IMPC) was prepared using magnesium oxide (MgO), monopotassium phosphate (KH₂PO₄), β-tricalcium phosphate (β-TCP), glucose and phosphoric acid solution. The effects of liquid to powder ratio(LPR), contents of MgO and glucose on IMPC’s gelling and mechanical properties were investigated. The results showed that increase of LPR and glucose content resulted in increased IMPC setting time and injectability, and decreased compressive strength. With the MgO content decreasing, the setting time and the injectability were decreased, whereas the compressive strength was increased. To obtain optimal formula for the new IMPC, the MgO and glucose contents and LPR were selected based on orthogonal experiments, and the result was 26wt% MgO, 6wt% glucose and 0.30 mL/g LPR. The new IMPC has moderate hydration with low exothermic reaction and ideal hardening performance, indicating that it may be used as a novel bone adhesive material.

Key words: magnesium-calcium phosphate cement, injectable, adhesive

CLC Number:

R318

DAI Hong-Lian, HU Fu-Jian, FANG Cai-Ping, LI Shi-Pu. Study on the Injectable Magnesium-calcium Phosphate Cements[J]. Journal of Inorganic Materials, 2014, 29(9): 991-996.

Figures/Tables 9

Fig. 1 Schematic illustration of cohesion test

Fig. 2 Effect of different contents on the setting time of IMPC

Fig. 3 Effect of different contents on the compressive strength of IMPC

Fig. 4 Effect of different contents on the injection rate of IMPC

Table 1 Scheme and results of the orthogonal experiments

No	MgO/ wt%	LPR/ (mL·g^-1)	Glucose/ wt%	Adhesive strength /MPa
1	24	0.25	5.0	1.41
2	24	0.30	6.0	1.66
3	24	0.35	7.0	1.31
4	26	0.25	6.0	2.21
5	26	0.30	7.0	2.13
6	26	0.35	5.0	1.78
7	28	0.25	7.0	1.93
8	28	0.30	5.0	1.86
9	28	0.35	6.0	1.68

Table 2 Cohesiveness results and range analysis

Factor	MgO/wt%	LPR/(mL·g^-1)	Glucose/wt%
K_1-3	4.44	5.61	5.11
K_4-6	6.12	5.65	5.55
K_7-9	5.47	4.77	5.37
R	1.68	0.88	0.44

Fig. 5 Exothermic rate curve for hydration of IMPC

Fig. 6 XRD patterns of IMPC after being hydrated for 24 h

Fig. 7 SEM images and EDAX of IMPC after being hydrated for 24 h (a) Column crystal; (b) Lamellar crystal

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