Journal of Inorganic Materials

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Progress in the Biomineralization Study of Bone and Enamel and Biomimetic Synthesis of Calcium Phosphate

DU Chang1,2,3, WANG Ying-Jun1,2,3   

  1. (1. Biomedical Engineering Institute, South China University of Technology, Guangzhou 510641, China; 2. Key Laboratory of Specially Functional Materials, Ministry of Education, Guangzhou 510641, China; 3. College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China)
  • Received:2009-04-01 Revised:2009-04-27 Published:2009-09-20 Online:2009-09-20

Abstract: Bone and enamel are typical biomineralized materials through organic matrix-mediated processes. The mineral phase in bone and enamel is mainly apatitic calcium phosphate, but their size, morphology and organization are depending on the different composition and property of the matrix in two tissues. This paper reviews the progress of biomineralization study of bone and enamel, in particular the current understanding on the hierarchical structure of the tissues, the self-assembly of matrix proteins and the mechanism of matrixmediated mineralization. The biomimetic synthesis of calcium phosphate for hard tissues repair and regeneration is also discussed.

Key words: bone, enamel, biomineralization, biomimetic synthesis

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