Preparation and Property of Strontium-substitutedHydroxyapatite

doi:10.3724/SP.J.1077.2011.00049

Abstract

Abstract: The biological HA in the body differs from that of pure HA in stoichiometry,composition, physical properties and mechanical properties, because this HA isparticularly prone to ion substitution. As a cation that can substitute forcalcium in the structure of hydroxyapatite, strontium provokes an increasinginterest because of its beneficial effect on bone formation, and prevention ofbone resorption. Here, strontium-substituted HA powders were prepared by thehydrothermal method at 180℃ for 8 h using Ca(NO₃)₂·4H₂O, (NH₄)₂HPO₄and Sr(NO₃)₂ as reagents. X-ray diffraction, Fouriertransform infrared spectroscope, transmission electron microscope, energy dispersiveX-ray, and thermogravimetric-differential thermal analysis were employed toinvestigate the crystalline phase, chemical composition, morphology, and thermalstability of the Sr-HA. And the cytotoxicity of Sr-HA was analyzed through MTT assay. The results showthat Sr is incorporated into the HA crystal structure and the crystal grainsize of the Sr-HA decreases as the Sr content (under 50wt%) is increased.Moreover, the HA thermal stability decreases. However, there’s no apparentdifference between the pure hydroxyapatite and all of the Sr-HA groups in cytotoxicity,which may have good biocompatibility.

Key words: strontium-substituted hydroxyapatite, synthesis, hydrothermalmethod, cytotoxicity

CLC Number:

LI Zhi-Hong,WU Ji-Min,HUAN Shu-Jie,GUAN Jin,ZHANG Xi-Zheng. Preparation and Property of Strontium-substitutedHydroxyapatite[J]. Journal of Inorganic Materials, 2011, 26(1): 49-54.

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