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无机材料学报

无机材料学报

• 研究论文 • 上一篇    下一篇

介孔硅基干凝胶的制备及其止血性能的研究

李晓生1, 刘昌胜1, 袁媛1, 王丽君2, 王秋云2   

  1. 1. 华东理工大学超细材料制备与应用教育部重点实验室, 教育部医用生物材料工程研究中心, 上海 200237; 2. 上海中医药大学中药学院, 上海 201203
  • 收稿日期:2007-02-13 修回日期:2007-07-11 出版日期:2008-03-20 网络出版日期:2008-03-20

Preparation and Hemostatic Properties of Mesoporous Silica-based Xerogels

LI Xiao-Sheng1, LIU Chang-Sheng1, YUAN Yuan1, WANG Li-Jun2, WANG Qiu-Yun2   

  1. 1. Key Laboratory for Ultrafine Materials of the Ministry of Education, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China; 2. Department of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2007-02-13 Revised:2007-07-11 Published:2008-03-20 Online:2008-03-20

PDF (PC)

1841

被引次数

18 | 5

摘要： 采用改进的溶胶-凝胶工艺合成了具有纳米介孔结构的硅基干凝胶, 并对其止血性能进行了研究. 通过X 射线衍射(XRD)、红外光谱(FTIR)、透射电镜(TEM)和N2等温吸附-脱附分析, 考察了合成硅基干凝胶的相态、结构、形貌、比表面积和介孔特征. 分别采用体外部分凝血活酶时间(APTT)和凝血酶原时间(PT)研究了硅基干凝胶及其加入量对内源性和外源性凝血系统的影响. 以传统止血剂云南白药为对比, 通过兔耳缘静脉止血实验评价了合成硅基干凝胶的止血性能. 结果表明: 经600℃煅烧可得到比表面积901.17m2/g、平均孔径3.255nm的非晶态硅基干凝胶; 合成的硅基干凝胶对内、外源性凝血因子活性均有明显的促进作用; 硅基干凝胶对兔耳缘静脉止血效果良好, 且比云南白药更显著.

关键词: 硅基干凝胶, 介孔, 比表面, 止血

Abstract: A biodegradable silica-based xerogel with nano-scale mesopores was synthesized by using improved sol-gel process, and its hemostatic properties were investigated. The phase state, chemical structure, surface morphology, specific surface areas and mesoporous structure of the synthesized silica-based xerogels were measured systemically by means of X-ray diffraction (XRD), infrared spectrum (FTIR), transmission electron microscope (TEM), and N2 adsoption-desoption (BET) techniques, respectively. The effects of the silica-based xerogel on intrinsic and extrinsic blood clotting systems were examined through the activated partial thromboplastin time (APTT) and prothrombin time (PT) tests in ~vitro, respectively. The hemostatic performance of the prepared silica-based xerogel was evaluated at the rabbit’s ear side veins compared with a traditional hemostatic dressing (Yunnan Baiyao). The results reveal that the non-crystalline silica-based xerogel with 901.17m2/g specific surface areas and 3.255nm in apertures is obtained after calcining at 600℃. The silica-based xerogel facilitates both of the intrinsic and extrinsic clotting activities significantly. The silica-based xerogel has good hemostatic effect on the rabbit’s ear side veins which is better than that of the Yunnan Baiyao.

Key words: silica-based xerogel, mesopore, specific surface area, hemostasis

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