Antibacterial Effect and the Mechanism of Cu2+, Zn2+ Bearing Nano-hydroxyapatite

Abstract

Abstract: Nano-hydroxyapatite (n-HA) slurry was synthesized at normal pressure, and Cu-bearing nano-hydroxyapatite (Cu-HA), Zn-bearing nano-hydroxyapatite (Zn-HA) and (Cu, Zn)-bearing
nano-hydroxyapatite (Cu-Zn-HA) were prepared by the ion exchange method in water medium. The properties of antibacterial materials were characterized by AAS, XRD and
TEM. The results of XRD analysis indicate that Cu²⁺ and Zn²⁺ can occupy Ca²⁺ site and also enter the lattice of hydroxyapatite.
The results of antibacterial experiments show that Cu-HA and Cu-Zn-HA have better antibacterial ability on E. coli and S. aureus, while the
antibacterial effect of Zn-HA is not significant. From the analysis of the antibacterial results, it can be concluded that two mechanisms play
the important role in the antibacterial ability, one is electrostatic attraction which making large amount of bacteria adhere on the n-HA surface, the other is the release of antibacterial metal ions slowly into
medium which can inhibit and kill bacteria.

Key words: nano-hydroxyapatite, Cu-bearing, antibacterial effect, antibacterial mechanism

CLC Number:

TQ455

LI Ji-Dong,LI Yu-Bao,WANG Xue-Jiang,YANG Wei-Hu,ZHOU Gang. Antibacterial Effect and the Mechanism of Cu²⁺, Zn²⁺ Bearing Nano-hydroxyapatite[J]. Journal of Inorganic Materials.

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Antibacterial Effect and the Mechanism of Cu²⁺, Zn²⁺ Bearing Nano-hydroxyapatite

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