Bismuth Sulfide Nanoclusters-loaded Silica-based Hybrid Micelles: Preparation and Photothermal Antibacterial Property

doi:10.15541/jim20240530

Abstract

Abstract:

As a new type of photothermal compound, bismuth-based nanomaterials have advantages of low toxicity, environmental friendliness, and cheap raw materials, showing great application potential in biological photothermal therapy, but their photothermal conversion efficiency and antibacterial property are still low. In this study, based on the confined gelation method reported by previous literature, a silica-based hybrid micellar precursor with organosilica- stabilized micellar cores was prepared using Pluronic polymer F127 and 3-mercaptopropyl-trimethoxy-silane as raw materials, and a facile “confined reduction/sulfuration” method was further developed, that is, the abundant thiol groups in the organosilica framework of the micelle core were used as restricted adsorption sites, sodium borohydride was used as reducing agent, and sodium sulfide was used as vulcanizing agent to prepare ultra-small and amorphous bismuth sulfide clusters-supported silica-based hybrid micellar system. The results show that the functional hybrid micellar system has excellent photothermal performance, and its photothermal conversion efficiency is up to 86.93%, which may be attributed to monodisperse and stable loading of bismuth sulfide clusters with defective structure in the organosilica framework of hybrid micellar system, which enhances light absorption capacity of bismuth sulfide nanomaterials in the near-infrared wavelength range. The in vitro antimicrobial experiments show that this bismuth- containing system exhibits excellent photothermal antibacterial properties under irradiation of 808 nm near-infrared laser and good biocompatibility.

Key words: silicon oxide, block copolymer, bismuth sulfide, photothermal property, antibacterial agent

CLC Number:

TQ174

ZHAO Lihua, WANG Yanshuai, YIN Xinwu, MAO Yeqiong, NIU Dechao. Bismuth Sulfide Nanoclusters-loaded Silica-based Hybrid Micelles: Preparation and Photothermal Antibacterial Property[J]. Journal of Inorganic Materials, 2025, 40(10): 1129-1136.

Figures/Tables 9

Fig. 1 Schematic diagram for the synthesis of BiS-FOMs

Fig. 2 HADDF-STEM images of (a) FOMs and (b) BiS-FOMs and corresponding element mappings

Fig. 3 (a) Size distributions, (b) Zeta potentials, (c) FT-IR spectra and (d) XRD patterns of FOMs, Bi-FOMs, and BiS-FOMs

Fig. 4 (a, b) XPS spectra and (c) Raman spectra of different samples

Fig. 5 Variations hydrodynamic diameters of BiS-FOMs in water, PBS (pH 7.4) and DMEM medium

Fig. 6 UV-Vis absorption spectra of BiS-FOMs Colorful figure is available on website

Fig. 7 Photothermal performance of FOMs, Bi-FOMs and BiS-FOMs (a, b) UV-Vis absorption spectra of samples with Bi concentration of 60 (a) and 600 mg/L (b); (c) Temperature-time curves of samples under 808 nm laser radiation for 5 min (power density of 1.5 W/cm2, Bi concentration of 600 mg/L ); (d) Temperature-time relationship of BiS-FOMs with different Bi concentrations under 808 nm laser irradiation for 5 min (power density of 1.5 W/cm2); (e) Temperature-time relationship of BiS-FOMs with Bi concentration at 600 mg/L under 808 nm laser irradiation with different power densities for 5 min; (f) Four ramp-up/down cycle curves of BiS-FOMs with or without laser radiation (1.5 W/cm2, 808 nm, 600 mg/L for Bi); (g) Photothermal conversion efficiency of BiS-FOMs (1.5 W/cm2, 808 nm, 600 mg/L for Bi); Colorful figures are available on website

Table 1 Photothermal conversion efficiency of reported Bi-based materials under 808 nm wavelength laser irradiation

Material	Photothermal conversion efficiency, η	Concentration/ (mg·L^-1)	Power density/ (W·cm^-2)	Ref.
Bi₂S₃	33.58%	100	0.75	[18]
Bi₂S₃-Au NRs	51.06%	100	0.75	[18]
Au/Bi₂S₃NFs	58.3%	180	2	[19]
Fe₃O₄@PDA@BSA-Bi₂S₃NPs	47.6%	900	1	[20]
Cu_1.94S-Bi₂S₃@PSIOAm NCs	31%	300	1	[21]
Au-Bi₂S₃ HNSCs	~15%	50	1	[22]
Au@Bi₂S₃	35.30%	125	2	[23]
Bi₂S₃/Cu₂S/Cu₃BiS₃	43.8%	200	0.75	[24]
BiS-FOMs	86.93%	600	1.5	This work

Fig. 8 Antibacterial effect and cytocompatibility of BiS-FOMs (a) Digital photos and (b) quantitetive colonies of Staphylococcus aureus treated with BiS-FOMs at different Bi concentrations under 808 nm laser (1.5 W/cm2) rediation for 10 min; (c) In vitro cell survival rates of HUVECs treated with BiS-FOMs at different Bi concentrations for 48 h

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