Aspirin on Ni-Ti-LDHs Nanosheets: Load and Sustained-release

doi:10.15541/jim20190074

Abstract

Abstract:

Aspirin/layered double hydroxides composite (A-LDHs) and aspirin/layered double hydroxide-nanosheets composite (A-LDHs-NS) were prepared by intercalation and exfoliation-recombination, respectively. Their morphology, drug loading property and drug loading mode of the composites were characterized by XRD, SEM, TG-DTG, and FT-IR. The releasing performances of aspirin from A-LDHs and A-LDHs-NS in the phosphate buffer solutions with different pH conditions were investigated. The results show that the typical lamellar structures are hold in as-prepared LDHs and LDHs-NS. The larger specific surface area (187 m ²·g ^-1) of LDHs-NS, the more aspirins are loaded on its surface, among which the max drug loading is 1.178 mmol·g ^-1. Its releasing process lasts for more than 1440 min, much longer than 20 min of the control materials, showing excellent sustained-releasing performance. This performance may because of the strong interaction between aspirin and LDHs-NS. Moreover, the sustained releasing performance is stronger at pH 7.4 than that at pH 4.8. All data from this study provides a reference for wider application of this kind of two-dimensional materials in biomedicine.

Key words: aspirin, layered double hydroxides nanosheet, drug loading, sustained-release, interaction mode

CLC Number:

TQ462

HU Li-Fang,LIU Liu,HE Jie,SUN Zhi-Peng,CHEN Xiao-Ping. Aspirin on Ni-Ti-LDHs Nanosheets: Load and Sustained-release[J]. Journal of Inorganic Materials, 2020, 35(2): 165-172.

Figures/Tables 9

Fig. 1 XRD patterns of as-prepared samples (a) Ni-Ti-LDHs; (b) A-LDHs-1; (c)A-LDHs-2; (d) A-LDHs-5; (e) Ni-Ti-LDHs-NS; (f) A-LDHs-NS-1; (g) A-LDHs-NS-2; (h) A-LDHs-NS-5

Fig. 2 SEM images of as-prepared samples (a) Ni-Ti-LDHs; (b) A-LDH-1; (c) Ni-Ti-LDHs-NS; (d)A-LDHs-NS-1

Fig. 3 TG-DTG curves of as-prepared samples (a) Ni-Ti-LDHs; (b) A-LDHs-1; (c)A-LDHs-2; (d) A-LDHs-5; (e) Ni-Ti-LDHs-NS; (f) A-LDHs-NS-1; (g) A-LDHs-NS-2; (h) A-LDHs-NS-5

Fig. 4 N2 adsorption-desorption isotherms of as-prepared samples (SBET represents the specific surface area) (a) Ni-Ti-LDHs; (b) Ni-Ti-LDHs-NS

Fig. 5 FT-IR spectra of A-LDHs and A-LDHs-NS after drug release (a) Ni-Ti-LDHs; (b) A-LDHs-1; (c) A-LDHs-2; (d) A-LDHs-5; (e) Ni-Ti-LDHs-NS; (f) A-LDHs-NS-1; (g) A-LDHs-NS-2; (h) A-LDHs-NS-5

Fig. 6 Schematic diagram of the composite model of aspirin with Ni-Ti-LDHs and Ni-Ti-LDHs-NS

Fig. 7 UV-Vis absorption spectra (a,a1) and standard operating curves (b,b1) of aspirin in PBS with pH=4.8 and 7.4

Fig. 8 UV-Vis absorption spectra of Ni-Ti-LDHs (a, a1) and Ni-Ti-LDHs-NS (b,b1) over time in PBS with pH=4.8 and 7.4

Fig. 9 Release curves of aspirin in PBS with pH=4.8 (A1, A2) and 7.4 (B1, B2) from different composites A-LDHs-1 (a), A-LDHs-2 (b), A-LDHs-5 (c), A-LDHs-NS-1 (d), A-LDHs-NS-2 (e), and A-LDHs-NS-5 (f)

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