Study on the Elution of the Adsorbed Serum Proteins on Biphasic Calcium Phosphate Ceramics

doi:10.3724/SP.J.1077.2013.13047

Abstract

Abstract: Two types of porous BCP ceramics were fabricated, using human serum as the model of protein solution. The effect of the different eluants and porous structure on the elution of the adsorbed serum proteins on BCP ceramics were investigated. The results showed that 400 mmol/L Na₃PO₄ solution had higher elution efficiency for the adsorbed serum proteins on BCP ceramics than 2 mol/L NaCl or 2% sodium dodecycl sufonate (SDS) solution. Moreover, the porous structure of BCP ceramics had a strong impact on the elution of the adsorbed serum proteins. The microporous structure could promote the adsorption of serum proteins on BCP ceramics and slowed down their release rate, but the 3D interconnected macropores were favorable for the elution and release of serum proteins from the BCP surface.

Key words: BCP ceramics, porous structure, eluants, protein adsorption, elution

CLC Number:

R318

WANG Jing, CHEN Ying, ZHU Xiang-Dong, FAN Yu-Jiang, ZHANG Xing-Dong. Study on the Elution of the Adsorbed Serum Proteins on Biphasic Calcium Phosphate Ceramics[J]. Journal of Inorganic Materials, 2013, 28(10): 1143-1147.

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