Preparation of Cefradine/ Montmorillonite Intercalation Compound

doi:10.3724/SP.J.1077.2012.00655

Abstract

Abstract: The cefradine/montmorillonite compounds were prepared by pharmaceutical montmorillonite (MMT) and sodium-montmorillonite (Na-MMT) by the method of solution intercalation. The drug load was quantitatively measured by UV spectrophotometry. The structures of compounds were determined by X-Ray Diffraction (XRD) and Fourier transformed infrared (FT-IR) spectroscope. The results show that cefradine can be intercalated into MMT mainly due to ion exchange, which cannot intercalate into MMT by mechanically mixing. Pharmaceutical MMT shows better ion exchange property after sodium modification, which is easily intercalated. The basal spacing of pharmaceutical MMT changes little after intercalation in water, however, the basal spacing of Na-MMT and pharmaceutical MMT after sodium modification increase.

Key words: montmorillonite, cefradine, ion exchange, solution intercalation

CLC Number:

TQ174

ZHAO Yan-Zhao, GUO Wen-Ji, WANG Lan. Preparation of Cefradine/ Montmorillonite Intercalation Compound[J]. Journal of Inorganic Materials, 2012, 27(6): 655-659.

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