CeO2 Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury

doi:10.15541/jim20250086

Abstract

Abstract: Acetaminophen overdose is a common cause of acute liver injury in clinical settings, characterized by the accumulation of reactive oxygen species (ROS) and infiltration of inflammatory cells. In this study, CeO₂clusterzymes (named as CeCs) of ultra-small size (around 1.3 nm) have been synthesized by a biomimetic mineralization process. The obtained CeCs present a high oxygen vacancy content (52.6%) and a high Ce³⁺/Ce⁴⁺ ratio (1.06), showing excellent adsorption and removal ability to a variety of reactive oxygen species (ROS, including free radicals), which can be used for hepatocyte protection. The in vivo animal experiments further confirmed that CeCs provided highly effective therapeutic intervention for acetaminophen-induced acute liver injury, extending the therapeutic window, and reversing sterile inflammation, underscoring their potential for clinical application.

Key words: cerium oxide, clusterzyme, acute liver injury, antioxidant, anti-inflammatory

CLC Number:

R318

YAN Mijia, ZHANG Jiale, ZHANG Qiuhong, CHEN Hangrong. CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250086.

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CeO₂ Clusterzymes: Biomimetic Synthesis and Treatment for Acute Liver Injury

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