可注射镁基磷酸钙骨水泥的研究

doi:10.15541/jim20130625

摘要/Abstract

摘要：

采用MgO、KH₂PO₄、β-TCP、葡萄糖作为骨水泥的固相, 磷酸溶液作为液相, 制备可注射镁基磷酸钙骨水泥(IMPC)。考察液固比(LPR)、MgO含量、葡萄糖含量变化对IMPC胶凝性能和力学性能的影响。实验结果显示: 液固比和缓凝剂葡萄糖含量增大均会导致凝结时间变长和抗压强度下降, 但有益于可注射性; 随MgO含量增大, 凝结时间缩短, 可注射率降低, 但抗压强度提高。采用正交实验法确定MgO含量26wt%, 液固比0.30 mL/g, 葡萄糖含量6wt%时得到的IMPC综合性能良好, 水化过程缓和, 放热量低。该IMPC有望成为一种新型骨粘结材料。

关键词: 镁基磷酸钙骨水泥, 可注射, 粘结

Abstract:

Injectable magnesium-calcium phosphate cements (IMPC) was prepared using magnesium oxide (MgO), monopotassium phosphate (KH₂PO₄), β-tricalcium phosphate (β-TCP), glucose and phosphoric acid solution. The effects of liquid to powder ratio(LPR), contents of MgO and glucose on IMPC’s gelling and mechanical properties were investigated. The results showed that increase of LPR and glucose content resulted in increased IMPC setting time and injectability, and decreased compressive strength. With the MgO content decreasing, the setting time and the injectability were decreased, whereas the compressive strength was increased. To obtain optimal formula for the new IMPC, the MgO and glucose contents and LPR were selected based on orthogonal experiments, and the result was 26wt% MgO, 6wt% glucose and 0.30 mL/g LPR. The new IMPC has moderate hydration with low exothermic reaction and ideal hardening performance, indicating that it may be used as a novel bone adhesive material.

Key words: magnesium-calcium phosphate cement, injectable, adhesive

中图分类号:

R318

戴红莲, 胡付俭, 方彩萍, 李世普. 可注射镁基磷酸钙骨水泥的研究[J]. 无机材料学报, 2014, 29(9): 991-996.

DAI Hong-Lian, HU Fu-Jian, FANG Cai-Ping, LI Shi-Pu. Study on the Injectable Magnesium-calcium Phosphate Cements[J]. Journal of Inorganic Materials, 2014, 29(9): 991-996.

图/表 9

图1 粘结性能测试示意图

Fig. 1 Schematic illustration of cohesion test

图 2 不同组分对IMPC凝结时间的影响

Fig. 2 Effect of different contents on the setting time of IMPC

图 3 不同组分对IMPC抗压强度的影响

Fig. 3 Effect of different contents on the compressive strength of IMPC

图 4 不同组分对IMPC可注射性的影响

Fig. 4 Effect of different contents on the injection rate of IMPC

表1 正交实验方案及结果

Table 1 Scheme and results of the orthogonal experiments

No	MgO/ wt%	LPR/ (mL·g^-1)	Glucose/ wt%	Adhesive strength /MPa
1	24	0.25	5.0	1.41
2	24	0.30	6.0	1.66
3	24	0.35	7.0	1.31
4	26	0.25	6.0	2.21
5	26	0.30	7.0	2.13
6	26	0.35	5.0	1.78
7	28	0.25	7.0	1.93
8	28	0.30	5.0	1.86
9	28	0.35	6.0	1.68

表2 IMPC粘结性能极差分析表

Table 2 Cohesiveness results and range analysis

Factor	MgO/wt%	LPR/(mL·g^-1)	Glucose/wt%
K_1-3	4.44	5.61	5.11
K_4-6	6.12	5.65	5.55
K_7-9	5.47	4.77	5.37
R	1.68	0.88	0.44

图5 IMPC水化的放热曲线

Fig. 5 Exothermic rate curve for hydration of IMPC

图6 24 h水化固化体XRD图谱

Fig. 6 XRD patterns of IMPC after being hydrated for 24 h

图7 24 h水化固化体SEM照片和EDAX分析结果

Fig. 7 SEM images and EDAX of IMPC after being hydrated for 24 h (a) Column crystal; (b) Lamellar crystal

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