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无机材料学报

无机材料学报

• 研究论文 • 上一篇    下一篇

BMP/α-磷酸三钙生物活性骨水泥的BMP释放动力学及成骨性能研究

杨为中1; 周大利1; 尹光福1; 尹绍雅2; 郑昌琼1; 高立达3   

  1. 1. 四川大学材料科学与工程学院, 成都 610064; 2. 天津环湖医院, 天津 300060; 3. 四川大学华西医院神经外科 成都 610041
  • 收稿日期:2003-10-08 修回日期:2003-11-28 出版日期:2004-11-20 网络出版日期:2004-11-20

BMP Releasing Kinetics and Osteogenesis Capacity of BMP/α-Tricalcium Phosphate Bone Cement

YANG Wei-Zhong1; ZHOU Da-Li1; YIN Guang-Fu1; YIN Shao-Ya2; ZHENG Chang-Qiong1; GAO Li-Da3   

  1. 1.Institute of Materials Science and Engineering; Sichuan University; Chengdu 610064; China; 2.Tianjin Huanhu Hospital; Tianjin 300060, China; 3.Department of Neurosurgery; West China Hospital of Sichuan University; Chengdu 610041; China
  • Received:2003-10-08 Revised:2003-11-28 Published:2004-11-20 Online:2004-11-20

PDF (PC)

1391

被引次数

6

摘要： 以骨组织工程学的方法制备了一种新型BMP/α-TCP复合骨水泥材料.通过体外蛋白质释放实验、强度实验及X射线衍射分析,考察了BMP在复合材料中的释放规律;通过组织学分析和X射线检查,研究了新型复合骨水泥材料对兔颅骨缺损的修复实验.结果表明:在模拟体内环境中,BMP自BMP/α-TCP复合材料中的释放规律符合Higuchi方程,BMP以扩散方式释放,BMF和α-TCP骨水泥复合后固化时间不受影响,BMP释放后材料强度随浸泡时间延长而增高,BMP释放4周后强度达到纯α-TCP骨水泥固化强度,X射线衍射分析表明材料向羟基磷灰石转化.骨缺损修复实验表明:新型骨水泥成骨能力强,能在短期内完全修复兔颅骨缺损.

关键词: α-磷酸三钙, 骨形态发生蛋白（BMP）, 骨水泥, 释放动力学, 成骨

Abstract: A novel BMP/α-TCP composite bone cement was developed by bone tissue engineering
approach. The releasing behavior of BMP from the composite was investigated in vitro through protein releasing testing, compressive
strength measurement and XRD analysis. With the help of histological study and X radiographic examination, the skull defect of rabbit was
repaired by the novel composite bone cement, and α-TCP bone cement was discussed as the control. Results in simulate body environment show
that the rules of BMP releasing from BMP/α-TCP composite agree with Higuchi equation, which indicate that BMP releasing accords with diffusion
model. The setting time of the bone cement is not influenced by the combination of BMP and α-TCP. After BMP releasing, the compressive
strength of materials increases with time, and the value reaches the level hardened pure α-TCP bone cement at fourth week. The crystalline
phase of materials is transferred into hydroxyapatite (HA) with time increasing. Animal experiments confirm the strong osteogenesis capacity of
the novel bone cement. Rabbit skull defect can be well healed with the materials in short period.

Key words: α-tricalcium phosphate （α-TCP）, bone morphogenetic protein （BMP）, bone cement, releasing kinetics, osteogenesis

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