双模型介孔SiO2二次孔结构对布洛芬装载和释放性能的影响

doi:10.3724/SP.J.1077.2012.00337

无机材料学报 ›› 2012, Vol. 27 ›› Issue (4): 337-342.DOI: 10.3724/SP.J.1077.2012.00337 CSTR: 32189.14.SP.J.1077.2012.00337

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双模型介孔SiO₂二次孔结构对布洛芬装载和释放性能的影响

高琳, 孙继红, 李育珍, 任博

(北京工业大学环境与能源工程学院, 北京100022)

收稿日期:2011-04-26 修回日期:2011-07-13 出版日期:2012-04-10 网络出版日期:2012-03-12
作者简介:高琳(1983-), 女, 博士研究生. E-mail: gaolin@email.bjut.edu.cn
基金资助:
国家自然科学基金(20851002, 21076003);国家重点基础研究发展规划项目(2009CB930200);北京市属市管高等学校人才强教计划(PHR200907105005, 005000543111517);北京市学术创新团队计划(PHR201107104)

Influence of Bimodal Mesopores Large Pore Structure on Ibuprofen Loading and Delivery Property

GAO Lin, SUN Ji-Hong, LI Yu-Zhen, REN Bo

(College of Energy Environmental & Engineering, Beijing University of Technology, Beijing 100022, China)

Received:2011-04-26 Revised:2011-07-13 Published:2012-04-10 Online:2012-03-12
About author:GAO Lin. E-mail: gaolin@email.bjut.edu.cn
Supported by:
National Natural Science Foundation of China (20851002, 21076003);973 Program (2009CB930200);Funding Program for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality of China (PHR200907105005, 005000543111517);Funding Program for Academic Innovation Team of Beijing (PHR201107104)

摘要/Abstract

摘要：

通过调整制备过程中的搅拌速度合成了具有不同二次孔结构的双模型介孔SiO₂纳米材料(BMMs), 进而通过3-(2-氨基乙基氨基)丙基三甲氧基硅烷对其表面修饰, 以布洛芬为模型药物, 重点考察了组装与缓释性能, 并根据Korsmeyer–Peppas方程分析其释放动力学行为. 采用XRD、TEM、N₂吸脱附曲线以及元素分析等多种表征手段, 结果表明通过改变搅拌速度可以改变正硅酸乙酯的水解和缩聚速度, 从而直接影响BMMs一级孔结构的有序度和由颗粒堆积而成的二级孔大小. 选用布洛芬作为药物模型, BMMs一级孔结构主要影响其药物的组装性能, 二级孔结构则主要影响药物分子的缓释行为, 二级孔越大, 释放速率越快.

关键词: 双模型介孔, SiO₂, 布洛芬, 装载, 释放

Abstract:

Three kinds of bimodal mesopores silica-based nanomaterials (BMMs) with different accumulated pores structure were synthesized by tuning the stirring rate in the preparation process and then functionalized with silane coupling agent 3-(2-aminoethylamino) propyltrimethoxysilane (NN-TES). The modified BMMs were used as ibuprofen carriers and their delivery property were studied with Korsmeyer-Peppas model. With the help of XRD, TEM, N₂ adsorption and desorption isotherms and elemental analysis, it indicated that the hydrolysis and condensation polymerization rate of TEOS would be influenced by changing the stirring rate, which resulted in the formation of three kinds of BMMs with different small pores order and large accumulated pores structure. When applying NN-TES modified BMMs as ibuprofen carriers, the ibuprofen loading amount in three different kinds of BMMs were almost the same, while the release rate had great difference from each other. These results demonstrate that the drug loading capacity was affected by the small pores of BMMs, while the large pores of BMMs would influence the drug diffusion behaviors in the mesoporous channels, leading to the increase of release rate with the increment of the large pore size.

Key words: bimodal mesopores, SiO₂, ibuprofen, loading, delivery

中图分类号:

高琳, 孙继红, 李育珍, 任博. 双模型介孔SiO₂二次孔结构对布洛芬装载和释放性能的影响[J]. 无机材料学报, 2012, 27(4): 337-342.

GAO Lin, SUN Ji-Hong, LI Yu-Zhen, REN Bo. Influence of Bimodal Mesopores Large Pore Structure on Ibuprofen Loading and Delivery Property[J]. Journal of Inorganic Materials, 2012, 27(4): 337-342.

图/表 5

图1 三种BMMs的XRD图谱 (a) BMMs-1; (b) BMMs-2; (c) BMMs-3

Fig. 1 XRD patterns of three kinds of BMMs

图2 三种BMMs的TEM照片及粒径分布图(插图)

Fig. 2 TEM images of three kinds of BMMs and typical particle size distribution (insert)

图3 氮气吸脱附曲线及相应的孔分布图(插图)

Fig. 3 N2 adsorption-desorption isotherms of three series of BMMs and their corresponding plots of the pore size distribution (insert)

图4 布洛芬在三种改性BMMs的装载曲线

Fig. 4 Loadings of Ibuprofen in three kinds of modified BMMs

图5 布洛芬在SBF中的释放曲线(A)和Korsmeyer-Peppas拟合曲线(B)

Fig. 5 Ibuprofen release profiles (A) and the initial 60wt% of ibuprofen release fitted with the Korsmeyer-Peppas model (B)

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双模型介孔SiO₂二次孔结构对布洛芬装载和释放性能的影响

Influence of Bimodal Mesopores Large Pore Structure on Ibuprofen Loading and Delivery Property

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