氨羧钾调控草酸钙晶体生长及其与分子结构的关系

doi:10.3724/SP.J.1077.2010.01185

无机材料学报 ›› 2010, Vol. 25 ›› Issue (11): 1185-1190.DOI: 10.3724/SP.J.1077.2010.01185 CSTR: 32189.14.SP.J.1077.2010.01185

氨羧钾调控草酸钙晶体生长及其与分子结构的关系

杨锦, 李君君, 袁欢欣, 欧阳健明

(暨南大学生物矿化与结石病防治研究所, 广州 510632)

收稿日期:2010-02-06 修回日期:2010-04-06 出版日期:2010-11-20 网络出版日期:2010-11-01
基金资助:
广东省科技攻关项目(2009B030801236); 国家自然科学基金(20971057)

Regulation of Potassium Aminocarboxylates on Calcium Oxalate Crystal Growth and Its Relationship with Molecular Structure

YANG Jin, LI Jun-Jun, YUAN Huan-Xin, OUYANG Jian-Ming

(Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China)

Received:2010-02-06 Revised:2010-04-06 Published:2010-11-20 Online:2010-11-01
Supported by:
Key Project of Science and Technology of Guangdong Province (2009B030801236); National Nature Science Foundation of China (20971057)

摘要/Abstract

摘要： 采用扫描电子显微镜(SEM)和X射线衍射(XRD)在凝胶体系中研究了不同结构氨羧钾对草酸钙(CaOxa)结晶的影响, 这些氨羧钾包括氨基乙酸钾(KGLY)、乙二醇二乙醚二胺四乙酸二钾(K₂EGTA)、氨基三乙酸二钾(K₂NTA)、二乙三胺五乙酸二钾(K₂DTPA)、乙二胺四乙酸二钾(K₂EDTA)和环已二胺四乙酸二钾(K₂CDTA). 这些物质均能诱导二水草酸钙(COD)形成, 抑制一水草酸钙(COM)聚集和减小COM的比表面积, 其诱导COD能力依次为: K₂DTPA (55wt%) > K₂EDTA≈K₂CDTA (50wt%) > K₂NTA (43wt%) >> K₂EGTA (4wt%) > KGLY (2wt%), 抑制COM聚集的能力依次为: K₂DTPA > K₂NTA > K₂CDTA≈K₂EDTA > K₂EGTA > KGLY. 从氨羧盐的分子结构、羧基的相对含量、羧基的空间位置、与钙离子的配位能力及其配位方式等角度讨论了其抑制COM聚集和诱导COD形成的化学基础. 结果表明K₂NTA和K₂DTPA有可能成为防止草酸钙结石形成的潜在药物.

关键词: 草酸钙, 氨基羧酸钾, 螯合剂, 生物矿化, 尿结石

Abstract: The effect of potassium aminocarboxylates on crystallization of calcium oxalate (CaOxa) was investigated in silica gel system by means of scanning electron microscopy and X-ray diffraction. These aminocarboxylates included potassium aminoacetate (KGLY), dipotassium glycoletherdiaminotetraacetate (K₂EGTA), dipotassium aminotriacetate (K₂NTA), dipotassium diethylenetriaminepenteacetate (K₂DTPA), dipotassium ethylene diamine tetraacetate (K₂EDTA) and dipotassium cyclohexanediamine tetraacetate (K₂CDTA). All these aminocarboxylates could induce the formation of calcium oxalate dihydrate (COD), inhibit the aggregation of calcium oxalate monohydrate (COM) and decrease the specific surface area of COM aggregates. The ability to induce COD formation follows the order: K₂DTPA (55wt%) > K₂EDTA ≈K₂CDTA (50wt%) > K₂NTA (43wt%) >> K₂EGTA (4wt%) > KGLY (2wt%), and the ability to inhibit COM aggregation follows the sequence: K₂DTPA>K₂NTA > K₂CDTA≈K₂EDTA > K₂EGTA > KGLY. These results are discussed in terms of their molecular structure, relative content of carboxylic groups, spatial location of carboxyl groups in aminocarboxylates, and their coordination capacity and modes with Ca²⁺ ions. It is proved that K₂NTA and K₂DTPA can be the potential drugs for preventing the formation of CaOxa stones.

Key words: calcium oxalate, potassium aminocarboxylates, chelators, biomineralization, urinary stone

中图分类号:

O611

杨锦, 李君君, 袁欢欣, 欧阳健明. 氨羧钾调控草酸钙晶体生长及其与分子结构的关系[J]. 无机材料学报, 2010, 25(11): 1185-1190.

YANG Jin, LI Jun-Jun, YUAN Huan-Xin, OUYANG Jian-Ming. Regulation of Potassium Aminocarboxylates on Calcium Oxalate Crystal Growth and Its Relationship with Molecular Structure[J]. Journal of Inorganic Materials, 2010, 25(11): 1185-1190.

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氨羧钾调控草酸钙晶体生长及其与分子结构的关系

Regulation of Potassium Aminocarboxylates on Calcium Oxalate Crystal Growth and Its Relationship with Molecular Structure

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