A Novel Technique to Prepare Porous 3D Fluoridated Hydroxyapatite Scaffold Using Pore-forming and Foaming Agents

doi:10.3724/SP.J.1077.2014.13309

Journal of Inorganic Materials ›› 2014, Vol. 29 ›› Issue (3): 289-293.DOI: 10.3724/SP.J.1077.2014.13309

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A Novel Technique to Prepare Porous 3D Fluoridated Hydroxyapatite Scaffold Using Pore-forming and Foaming Agents

GONG Meng-An^1,2, Rao Qun-Li¹, WANG Hong-Lie³

(1. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China; 3. Department of Oral Medicine, University of Michigan, Michigan 48109, America)

Received:2013-06-15 Revised:2013-08-21 Published:2014-03-20 Online:2014-02-18
About author:GONG Meng-An. E-mail:zhizhedayu@163.com
Supported by:
Graduate Creative Ability Special Fund of Shanghai Jiao Tong University(z-404-001)

Abstract

Abstract:

A novel technology using pore-forming agent and foaming agent was developed to prepare multi-porous fluoridate hydroxyapatite scaffolds. With this technology, scaffolds were produced with uniform and highly interconnected pores in which large pores containing small ones on their walls distributing along 3-dimension. First, the precursor, FHA powder, was prepared by chemical precipitation method. Then it was used to form scaffold through heat treatments by adding ammonium bicarbonate as foaming agent and polymethyl methacrylate as pore-forming agent, and a dense frame of multi-porous structure was obtained. Investigated by X-ray diffraction (XRD), a dual-phase of FHA/β-TCP in scaffold was confirmed. The uniform morphology in scaffolds and the pore size distribution of large pores (100-400 µm) containing small ones (10~50 µm) were demonstrated by SEM images. HA and β-TCP were also used to prove the universality of this method. Furthermore, the pore formation and its mechanism were discussed in detail.

Key words: ammonium bicarbonate, polymethyl methacrylate, fluoridated hydroxyapatite, multi-porous scaffold

CLC Number:

TQ174

GONG Meng-An, Rao Qun-Li, WANG Hong-Lie. A Novel Technique to Prepare Porous 3D Fluoridated Hydroxyapatite Scaffold Using Pore-forming and Foaming Agents[J]. Journal of Inorganic Materials, 2014, 29(3): 289-293.

Figures/Tables 6

Fig. 1 XRD patterns for HA(a), FHA(b), β-TCP(c), Sintered FHA at 1000℃(d) and FHA scaffold(e)

Fig. 2 SEM images of FHA powders prepared by chemical precipitation method at low (a) and high (b) magnification

Fig.3 SEM images of prepared porous FHA scaffolds under different heat treatments (a) Drying at 50℃; (b) Sintered at 1000℃

Fig. 4 SEM images of porous FHA scaffold showing the sintered structure of pores (a) and wall of pore (b)

Fig. 5 SEM images of porous FHA scaffold under different heat treatment processes (a) Sintered at 1000℃ without ammonium bicarbonate; (b) Drying at 35℃; (c) Drying at 60℃; (d) Sintered at the rate of 5℃/min to 1000℃

Fig. 6 SEM images of HA (a) and β-TCP (b) scaffold showing the sintered porous structure

References 14

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A Novel Technique to Prepare Porous 3D Fluoridated Hydroxyapatite Scaffold Using Pore-forming and Foaming Agents

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