上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展 无机材料学报    2025, 40 (2): 145-158.   DOI:10.15541/jim20240058

图13 NaYF₄: Yb, Er@mSiO₂@Ce6&α-酮戊二酸&GOx@mMnO₂@HA(UCAGMH)纳米平台在乳腺肿瘤治疗中的应用^[73]

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在双模态成像的基础上能否实现三模等多模态成像并应用于临床, 非常值得探讨。Yan等[73]构建了尺寸约为60 nm的NaYF₄: Yb, Er@mSiO₂@Ce6&α-酮戊二酸&GOx@mMnO₂@HA(UCAGMH)复合智能药物递送纳米平台, 实现了荧光/CT/MRI多模态影像引导下的乳腺癌治疗和肝转移预防(图13)。MnO₂被酸性物质迅速降解, 产生大量的Mn2+和O₂。Mn2+可作为MRI的造影剂和理想的芬顿类药剂, 而O₂通过缓解缺氧和促进葡萄糖氧化酶(GOx)对瘤内葡萄糖(Glu)的氧化, 从而促进PDT。

(a) Linear correlation between longitudinal relativities (r₁) and equivalent Mn concentrations of MUCNPs@BPNs-Ce6 at pH 6, with insets showing T1-weighted MR images of MUCNPs@BPNs-Ce6 solution at various Mn concentrations; (b) Linear correlation between longitudinal relativities (r₂) and equivalent Fe concentrations of MUCNPs@BPNs-Ce6, with insets showing T2-weighted MR images of MUCNPs@BPNs-Ce6 solution at various Fe concentrations; (c) Blood time activity curve for MUCNPs@BPNs-Ce6 by measuring Fe concentration; (d) In vivo MR images of the tumor of mice before and after injection with MUCNPs@BPNs-Ce6 for 24 h; (e) T1-weighted MR signals in the tumor before and after injection with MUCNPs@BPNs-Ce6 for 24 h; (f) Biodistribution results of HeLa tumor-bearing mice before and after injection with MUCNPs@BPNs-Ce6 in MRI for 24 h; (g) In vivo fluorescence images of HeLa tumor-bearing mice before and after injection with MUCNPs@BPNs-Ce6 for 24 h; (h) Ex vivo fluorescence images of organs and tumor after injection with MUCNPs@BPNs-Ce6 for 24 h; (i) In vivo ultrasonic imaging of HeLa tumor-bearing mice after injection with MUCNPs@BPNs-Ce6 for different time ...