上转换荧光探针辅助的光学成像技术在肿瘤显影中的应用研究进展

海热古·吐逊, 郭乐, 丁嘉仪, 周嘉琪, 张学良, 努尔尼沙·阿力甫

Research Progress of Optical Bioimaging Technology Assisted by Upconversion Fluorescence Probes in Tumor Imaging

HAIREGU Tuxun, GUO Le, DING Jiayi, ZHOU Jiaqi, ZHANG Xueliang, NUERNISHA Alifu

图13 NaYF4: Yb, Er@mSiO2@Ce6&α-酮戊二酸&GOx@mMnO2@HA(UCAGMH)纳米平台在乳腺肿瘤治疗中的应用[73]

Fig. 13 Schematic illustration of therapy strategy of NaYF4: Yb, Er@mSiO2@Ce6&α-ketoglutaric acid&GOx@mMnO2@HA (UCAGMH) nanoplatforms for breast tumors[73] (a) Therapeutic mechanism of UCAGMH in the mouse breast tumor model; (b) Key role that UCAGMH plays in MRI, CT and FI for therapy guidance in which HA can target CD44 receptors and induce nanoparticles to enter cells through phagocytosis