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无机材料学报

无机材料学报 ›› 2026, Vol. 41 ›› Issue (6): 839-846.DOI: 10.15541/jim20250319 CSTR: 32189.14.10.15541/jim20250319

• 研究快报 • 上一篇    下一篇

锰掺杂多金属氧酸盐增强活性氧清除能力用于细胞保护

曲博渲1,2(), 谭继1(), 陈书寒1, 刘宣勇1()   

  1. 1 中国科学院 上海硅酸盐研究所, 关键陶瓷材料全国重点实验室, 上海 200050
    2 中国科学院大学 材料科学与光电工程中心, 北京 100049

Enhanced ROS Scavenging Property of Polyoxometalates by Manganese Doping for Cytoprotection

QU Boxuan1,2(), TAN Ji1(), CHEN Shuhan1, LIU Xuanyong1()   

  1. 1 State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
    2 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2025-07-30 Revised:2025-09-22 Published:2026-06-20 Online:2026-05-29
  • Contact: TAN Ji, associate professor. E-mail: tanji@mail.sic.ac.cn;
    LIU Xuanyong, professor. E-mail: xyliu@mail.sic.ac.cn
  • About author:QU Boxuan (1998-), male, Master candidate. E-mail: quboxuan@mail.ustc.edu.cn
  • Supported by:
    National Key Research and Development Program of China(2022YFC2403000)

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摘要：

活性氧(ROS)的过量积累会导致细胞发生氧化应激而死亡。纳米酶是一类具有类似天然酶催化活性的纳米材料, 可清除ROS保护细胞免受氧化损伤。多金属氧酸盐(POMs)具有良好的氧化还原性和生物相容性, 是一种潜在的纳米酶材料, 但POMs较低的催化活性限制了其应用。本研究通过锰(Mn)掺杂策略有效增强了Keggin型POMs ([PMo12O40]3-)的类酶活性, 发现适量Mn掺杂可增强该POMs的类过氧化氢酶和类超氧化物歧化酶活性, 进而清除过量ROS保护细胞免受氧化应激损伤。本研究探讨了Mn掺杂水平、POMs结构与催化活性之间的关系, 发现Mn与Mo-O框架之间的协同电子作用是增强其类过氧化氢酶活性的关键因素。本研究初步探索了POMs基纳米酶的优化设计策略, 研究结果可为抗氧化纳米酶的开发提供一定的科学参考。

关键词: 多金属氧酸盐, 氧化应激, 纳米酶, 催化医学

Abstract:

Excessive accumulation of reactive oxygen species (ROS) can trigger oxidative stress in cells, ultimately leading to cell death. Nanozymes, a class of nanomaterials with enzyme-like catalytic activity, are capable of scavenging ROS and protecting cells from oxidative damage. Polyoxometalates (POMs), known for their favorable redox properties and biocompatibility, have been considered as potential nanozyme candidates. However, their relatively low catalytic activity has hindered their practical applications. In this study, an isomorphic doping strategy with manganese (Mn) was employed to effectively enhance the enzyme-like activity of Keggin-type POMs ([PMo12O40]3-). It was found that appropriate Mn doping significantly improved both the catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities of the POMs, thereby enhancing its ability to eliminate excessive ROS and protect cells from oxidative stress-induced damage. The relationships among Mn doping levels, POMs structure, and catalytic activity were systematically investigated. The results suggest that the synergistic electronic interaction between Mn and Mo-O framework plays a crucial role in enhancing the CAT-like activity of the material. This work provides a preliminary exploration of design strategies for POMs-based nanozymes and offers scientific insights for the development of antioxidant nanozymes.

Key words: polyoxometalate, oxidative stress, nanozyme, catalytic medicine

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