锰掺杂多金属氧酸盐增强活性氧清除能力用于细胞保护

doi:10.15541/jim20250319

无机材料学报

锰掺杂多金属氧酸盐增强活性氧清除能力用于细胞保护

曲博渲^1,2, 谭继¹, 陈书寒¹, 刘宣勇¹

1.中国科学院上海硅酸盐研究所关键陶瓷材料全国重点实验室,上海 200050;
2.中国科学院大学材料科学与光电工程中心,北京 100049

收稿日期:2025-07-30 修回日期:2025-09-22
通讯作者: 谭继, 副研究员. E-mail: tanji@mail.sic.ac.cn; 刘宣勇, 研究员. E-mail: xyliu@mail.sic.ac.cn
作者简介:曲博渲(1998-), 男, 硕士研究生. quboxuan@mail.ustc.edu.cn

Enhanced ROS Scavenging Property of Polyoxometalates by Manganese Doping for Cytoprotection

QU Boxuan^1,2, TAN Ji¹, CHEN Shuhan¹, LIU Xuanyong¹

1. State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Received:2025-07-30 Revised:2025-09-22
Contact: TAN Ji, associate professor. E-mail: tanji@mail.sic.ac.cn; LIU Xuanyong, professor. E-mail: xyliu@mail.sic.ac.cn
About author:QU Boxuan(1998–), male, Master candidate. E-mail: quboxuan@mail.ustc.edu.cn
Supported by:
National Key Research and Development Program of China (2022YFC2403000)

摘要/Abstract

摘要： 活性氧（ROS）的过量积累会导致细胞发生氧化应激而死亡。纳米酶是一类具有类似天然酶催化活性的纳米材料,可清除活性氧保护细胞免受氧化损伤。多金属氧酸盐（POMs）具有良好的氧化还原性和生物相容性,是一种潜在的纳米酶材料,但POMs较低的催化活性限制了其应用。本研究通过锰（Mn）同构掺杂策略有效增强了Keggin型POM（[PMo₁₂O₄₀]³⁻）的类酶活性。发现适量Mn掺杂可增强该POM的类过氧化氢酶和类超氧化物歧化酶活性,进而清除过量活性氧保护细胞免受氧化应激损伤。本研究探讨了Mn掺杂水平、POM结构与催化活性之间的关系,发现Mn与Mo-O框架之间的协同电子作用是增强其类过氧化氢酶活性的关键因素。本研究初步探索了POMs基纳米酶的优化设计策略,结果可为抗氧化纳米酶的开发提供一定的科学参考。

关键词: 多金属氧酸盐, 氧化应激, 纳米酶, 催化医学

Abstract: Excessive accumulation of reactive oxygen species (ROS) can trigger oxidative stress in cells, ultimately leading to cell death. Nanozymes, a class of nanomaterials with enzyme-like catalytic activity, are capable of scavenging ROS and protecting cells from oxidative damage. Polyoxometalates (POMs), known for their favorable redox properties and biocompatibility, have been considered as potential nanozyme candidates. However, their relatively low catalytic activity has hindered their practical applications. In this study, an isomorphic doping strategy with manganese (Mn) was employed to effectively enhance the enzyme-like activity of Keggin-type POM ([PMo₁₂O₄₀]^3⁻). It was found that appropriate Mn doping significantly improved both the catalase-like and superoxide dismutase-like activities of the POM, thereby enhancing its ability to eliminate excessive ROS and protect cells from oxidative stress-induced damage. The relationship among Mn doping levels, POM structure, and catalytic activity was systematically investigated. The results suggest that the synergistic electronic interaction between Mn and the Mo-O framework plays a crucial role in enhancing the catalase-like activity of the material. This work provides a preliminary exploration of design strategies for POM-based nanozymes and offers scientific insights for the development of antioxidant nanozymes.

Key words: polyoxometalates, oxidative stress, nanozyme, catalytic medicine

中图分类号:

TQ171

曲博渲, 谭继, 陈书寒, 刘宣勇. 锰掺杂多金属氧酸盐增强活性氧清除能力用于细胞保护[J]. 无机材料学报, DOI: 10.15541/jim20250319.

QU Boxuan, TAN Ji, CHEN Shuhan, LIU Xuanyong. Enhanced ROS Scavenging Property of Polyoxometalates by Manganese Doping for Cytoprotection[J]. Journal of Inorganic Materials, DOI: 10.15541/jim20250319.

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