无机材料学报 ›› 2021, Vol. 36 ›› Issue (1): 81-87.DOI: 10.15541/jim20200394

• 研究论文 • 上一篇    下一篇

光热/pH响应B-CuS-DOX纳米药物用于化疗-光热协同治疗肿瘤

谢雪1,2,吴建荣2,蔡晓军2,郝俊年2,郑元义1,2()   

  1. 1. 重庆医科大学 超声分子影像重点实验室, 重庆400010
    2. 上海交通大学附属第六人民医院, 上海超声医学研究所, 上海 200233
  • 收稿日期:2020-07-14 修回日期:2020-08-13 出版日期:2021-01-20 发布日期:2020-08-28
  • 作者简介:谢雪(1992-), 女, 硕士研究生. E-mail: xiexue_moderation@163.com
  • 基金资助:
    国家自然科学基金国际合作重点项目(81720108023);国家重点研究发展计划(2018YFC0115200)

Photothermal/pH Responsive B-CuS-DOX Nanodrug for Chemo-photothermal Synergistic Therapy of Tumor

XIE Xue1,2,WU Jianrong2,CAI Xiaojun2,HAO Junnian2,ZHENG Yuanyi1,2()   

  1. 1. Institute of Ultrasound Molecular Imaging, Chongqing Medical University, Chongqing 400010, China
    2. Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China
  • Received:2020-07-14 Revised:2020-08-13 Online:2021-01-20 Published:2020-08-28
  • About author:XIE Xue (1992-), female, Master candidate. E-mail: xiexue_moderation@163.com
  • Supported by:
    The Key Project of International Cooperation and Exchange of NSFC(81720108023);National Key Research and Development Program(2018YFC0115200)

摘要:

基于纳米材料的化疗-光热协同治疗是一种高效的肿瘤治疗方式, 但如何构建具有高载药量与良好光热转换性能的纳米药物依然面临挑战。本研究通过超声剥离法制备二维硼(boron, B)纳米片, 进一步在其表面原位负载超小粒径硫化铜(CuS)纳米颗粒和化疗药阿霉素(DOX), 形成B-CuS-DOX纳米药物。B-CuS具有高的DOX药物装载能力(864 mg/g)和优异的光热转化性能(在808 nm处的光热转换效率为55.8%), 同时可实现pH及近红外激光双重刺激响应而释放药物。细胞实验表明在808 nm近红外光的照射下, B-CuS-DOX展示了良好的化疗-光热协同治疗效果。本研究构建的纳米药物有望为体内肿瘤治疗提供一种有效的化疗-光热协同治疗策略。

关键词: 硼纳米片, 药物递送, 光热治疗, 刺激响应, 肿瘤, 协同治疗

Abstract:

Nanoparticles-based drug delivery system for synergetic chemo-photothermal therapy is an efficient strategy for tumor therapy. However, construction of nanodrugs with high drug loading capacity and good photothermal conversion property is still a great challenge. In this work, two-dimensional boron nanosheets were prepared by ultrasonic liquid exfoliation method, which were further loaded with ultra-small copper sulfide (CuS) nanoparticles and doxorubicin (DOX) to obtain B-CuS-DOX nanocomposites. The prepared B-CuS-DOX exhibited high drug loading capacity (864 mg/g) and excellent photothermal conversion efficiency (55.8%). In addition, B-CuS-DOX exhibited pH and laser--responsive drug release behavior. In vitro results demonstrated that the prepared B-CuS-DOX achieved a good synergistic effect of chemotherapy and photothermal therapy. This work is expected to provide an effective chemo-photothermal synergistic therapy strategy for tumor therapy.

Key words: boron nanosheet, drug delivery, photothermal therapy, stimulus-responsive, tumor, synergistic therapy

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