Preparation and Characterization of Magnetic Norfloxacin Gelatin Microspheres

Abstract

Abstract: Based on the biological compatibility of gelatin in water and its solidification by glutaradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by
means of the reverse phase suspension cold-condensation method using Fe₃O₄ as core and glutaric dialdehycle as dispersed medium. The products were
characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres
is in the rang from 5 to 10μm, The content of drug in microspheres is 6.2% and of Fe₃O₄ is 19%. The drug encapsulation efficiency is 61.4%,
the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing.

Key words: gelatin, norfloxacin, magnetic microsphere, controlled release

CLC Number:

TM277
TQ174

WANG Yan-Qing,ZHANG Chao-Ping. Preparation and Characterization of Magnetic Norfloxacin Gelatin Microspheres[J]. Journal of Inorganic Materials.

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Preparation and Characterization of Magnetic Norfloxacin Gelatin Microspheres

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