Journal of Inorganic Materials ›› 2023, Vol. 38 ›› Issue (7): 750-762.DOI: 10.15541/jim20220580
Special Issue: 【生物材料】骨骼与齿类组织修复(202409)
• REVIEW • Previous Articles Next Articles
ZHAO Rui1,2(
), MAO Fei1, QIAN Hui1(), YANG Xiao2, ZHU Xiangdong2, ZHANG Xingdong2
Received:2022-09-30
Revised:2022-10-27
Published:2023-03-06
Online:2023-03-06
Contact:
QIAN Hui, professor. E-mail: 1000007341@ujs.edu.cnAbout author:ZHAO Rui (1995-), female, PhD, lecturer. E-mail: 1000005729@ujs.edu.cn
Supported by:CLC Number:
ZHAO Rui, MAO Fei, QIAN Hui, YANG Xiao, ZHU Xiangdong, ZHANG Xingdong. Micro-/Nano-structured Biomaterials for Bone Regeneration: New Progress[J]. Journal of Inorganic Materials, 2023, 38(7): 750-762.
Fig. 1 Schematic diagram of bone hierarchical structural organization (up part) and scanning electron microscope images (bottom part) of the cortical bone specimens located at human femoral diaphysis[1,11] In bone tissue, macroscale arrangements involve both compact/ cortical bone at the surface and spongy/trabecular bone in the interior. Compact bone is composed of osteons and Haversian canals, which surrounded by blood vessels. Osteons have a lamellar structure, with individual lamella consisting of fibers arranged in geometrical patterns. The fibers comprise several mineralized collagen fibrils, composed of collagen protein molecules formed from three chains of amino acids and nanocrystals of hydroxyapatite, and linked by an organic phase to form fibril arrays
Fig. 2 Schematic diagram of preparation process and bone forming ability of traditional calcium phosphate (CaP), whiskered calcium phosphate (wCaP) and micro-/nano-structured calcium phosphate (nwCaP) bioceramics with different surface morphologies[33]
Fig. 3 Illustration of the possible molecular mechanism involved in nwCaP bioceramics induced osteogenic effect[33] (a) Photos of Alizarin Red S and von Kossa stainings; (b) Cluster analysis of genes and quantitative qRT-PCR analysis expressions; (c) Osteogenesis-related gene expression; (d) Representative western blot analysis; OVX: Ovariectomized
Fig. 4 CD31 and EMCN staining of histological sections from the micro-/nano-structured hydroxyapatite bioceramic groups[16] Green fluorescence: CD31; Red fluorescence: EMCN; Blue fluorescence: Nucleus of the cells
Fig. 5 In vivo sequential fluorescence labeling of new bone formation inside porous nwHA bioceramics[16] (a) Observed patterns of new bone formation (yellow: tetracycline label; green: calcein label); (b) Two types of osteogenesis discovered inside the pore structure of nwHA bioceramics (green indicating CD 31, Red indicating EMCN, and blue indicating nucleus); (c) Comparison of mineral apposition rate (MAR) between different nwHA groups, with statistical analysis of the relationship between osteogenesis type and pore diameter of the bioceramics, and the relationship between osteogenesis type and MAR
| Material | Synthesis method | In vitro results | Animal model | In vivo results | Ref. |
|---|---|---|---|---|---|
| β-TCP scaffolds with micro/ nano surface topography | DLP printing and in situ growth crystal process | Promote osteogenic differentiation of stem cells | Rat skull defects | Improve the bone regeneration | [ |
| Micro/nano-scale titania fiber-like network on the surface of Ti implants | One-step alkaline treatment in NaOH solution | Facilitate osteogenic and angiogenic differentiation of BMSCs and endothelial cells; Suppress M1 macrophages and stimulate M2 phenotype | Rabbit femur defects | Induce ameliorative osseointegration | [ |
| MNBG/PLGA bi-layered membranes | Electrospinning | Promote osteogenesis | [ | ||
| Micro-nano rough Ti6Al4V | Acid etch process | Improve osteogenic differentiation of MSCs | [ | ||
| HA bioceramics with submicron- to nano- topographies | Sintering | Maintain the conformation of BMP-2, activate the osteogenic differentiation of BMSCs | Canine intramuscular implantation | Process excellent bone-like apatite forming ability and outstanding osteoinductivity | [ |
| HA with micro/nano hierarchical structures | Photolithography and hydrothermal techniques | Promote osteogenic differentiation of hBMSCs and angiogenic acticvity of HUVECs | [ | ||
| β-TCP/CaSiO3 composite ceramics with micro/ nano-HAp the surface layer | 3D bioplotting and hydrothermal treatment | Upregulate the cellular differentiation of mBMSCs and gene expression of HUVECs | Ectopic subcutaneous implantation at the back of rats | Promote capillary formation and bone augmentation | [ |
| PEEK/CF/n-HA ternary biocomposite with micro/ nano-topographical surface | Oxygen plasma and sandblasting | Promote the proliferation and differentiation of MG-63 cells | Dog mandibles | Boost the osseointegration between implant and bone | [ |
| Micro/nano structural silicon nitride and PEKK composite | Femtosecond laser ablation | Promote osteogenic differentiation of rBMSCs; Exhibit a greater bacteriostatic activity | Rabbit femur cavity defect | Promote osseointegration and bone repair | [ |
| Silicate-based bioceramic with micro-nano surfaces and hollow channels | 3D printing and hydrothermal treatment | Facilitate the attachment and proliferation of BMSCs | Rabbit femur defects | Boost the newly bone formation | [ |
| PLLA/CS composite scaffold with micro/nano- fiber hierarchical structure | 3D printing and thermally induced phase separation technology | Promote cell adhesion and proliferation | [ |
Table 1 Summary of previous work on bone formation in the micro-/nano-structured biomaterials
| Material | Synthesis method | In vitro results | Animal model | In vivo results | Ref. |
|---|---|---|---|---|---|
| β-TCP scaffolds with micro/ nano surface topography | DLP printing and in situ growth crystal process | Promote osteogenic differentiation of stem cells | Rat skull defects | Improve the bone regeneration | [ |
| Micro/nano-scale titania fiber-like network on the surface of Ti implants | One-step alkaline treatment in NaOH solution | Facilitate osteogenic and angiogenic differentiation of BMSCs and endothelial cells; Suppress M1 macrophages and stimulate M2 phenotype | Rabbit femur defects | Induce ameliorative osseointegration | [ |
| MNBG/PLGA bi-layered membranes | Electrospinning | Promote osteogenesis | [ | ||
| Micro-nano rough Ti6Al4V | Acid etch process | Improve osteogenic differentiation of MSCs | [ | ||
| HA bioceramics with submicron- to nano- topographies | Sintering | Maintain the conformation of BMP-2, activate the osteogenic differentiation of BMSCs | Canine intramuscular implantation | Process excellent bone-like apatite forming ability and outstanding osteoinductivity | [ |
| HA with micro/nano hierarchical structures | Photolithography and hydrothermal techniques | Promote osteogenic differentiation of hBMSCs and angiogenic acticvity of HUVECs | [ | ||
| β-TCP/CaSiO3 composite ceramics with micro/ nano-HAp the surface layer | 3D bioplotting and hydrothermal treatment | Upregulate the cellular differentiation of mBMSCs and gene expression of HUVECs | Ectopic subcutaneous implantation at the back of rats | Promote capillary formation and bone augmentation | [ |
| PEEK/CF/n-HA ternary biocomposite with micro/ nano-topographical surface | Oxygen plasma and sandblasting | Promote the proliferation and differentiation of MG-63 cells | Dog mandibles | Boost the osseointegration between implant and bone | [ |
| Micro/nano structural silicon nitride and PEKK composite | Femtosecond laser ablation | Promote osteogenic differentiation of rBMSCs; Exhibit a greater bacteriostatic activity | Rabbit femur cavity defect | Promote osseointegration and bone repair | [ |
| Silicate-based bioceramic with micro-nano surfaces and hollow channels | 3D printing and hydrothermal treatment | Facilitate the attachment and proliferation of BMSCs | Rabbit femur defects | Boost the newly bone formation | [ |
| PLLA/CS composite scaffold with micro/nano- fiber hierarchical structure | 3D printing and thermally induced phase separation technology | Promote cell adhesion and proliferation | [ |
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