Preparation of BIT-layered Double Hydroxide and the Study of Antifungal Properties

doi:10.3724/SP.J.1077.2013.12681

Abstract

Abstract: Mg-Al layered double hydroxides, loaded with 1,2-benzisothiazolin-3-ketone(Mg₂Al-BIT LDH), were synthesized via coprecipitation method. The resulting compounds were characterized by X-ray diffraction, Fourier transform infrared spectroscope and scanning electron microscope. Drug release kinetics were studied in the medium with pH at 4.8 and 7.2. The results showed that BIT was successfully inserted into the LDH inter layers, with a drug loading rate of 44.35%。The release kinetics process was in line with the quasi-second-order equation. The results showed that the antifungal effects of BIT were worse than that of Mg₂Al-BIT LDHs in the final phase of the mold test due to its consumption, dissolution and precipitation, suggesting Mg₂Al-BIT LDHs nano-hybrid a better anti-mildew duration.

Key words: layered double hydroxides, BIT, sustained-release, anti-mildew duration

CLC Number:

TG172

ZHANG Yi-Xuan, LI Song-Mei, LIU Jian-Hua, YU Mei. Preparation of BIT-layered Double Hydroxide and the Study of Antifungal Properties[J]. Journal of Inorganic Materials, 2013, 28(9): 1025-1032.

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