Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

doi:10.3724/SP.J.1077.2013.12176

Journal of Inorganic Materials ›› 2013, Vol. 28 ›› Issue (1): 74-78.DOI: 10.3724/SP.J.1077.2013.12176

• Orginal Article • Previous Articles Next Articles

Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

ZHAO Jing¹, LI Jin-Yu², ZHI Wei², LU Xiong², JIA Zhi-Bin², WENG Jie²

(1. School of Mechanial Engineering, Southwest Jiaotong University, Chengdu 610031; 2. Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031)

Received:2012-03-20 Revised:2012-09-18 Published:2013-01-10 Online:2012-12-20
About author:ZHAO Jing. E-mail: jzhao@swjtu.edu.cn
Supported by:
National Basic Research Program of China (2012CB933602);National Natural Science Foundation of China (51205327, 51172188);Fundamental Research Funds for the Central Universities (A0920502051113-95);Sichuan Science and Technology Fundation for Young Scholar Innovation Groups (2010JQ0081)

Abstract

Abstract:

Interconnectivity of tissue engineering scaffolds plays a very important role in biological performance in vivo. In this work, chitin sol and wax spheres were used for preparing porous hydroxyapatite (HA) ceramics scaffolds by particle leaching and gel-casting methods. Under the same mounded casting condition, the effect of ratio of slurry/wax pore former on porosity, shrinkage, interconnectivity, porous structure and compressive strength were investigated systematically. Porous HA ceramic scaffolds were evaluated by gravimetric method, stereomicroscope, X-ray diffraction (XRD), scanning electron microscope (SEM) and universal testing machine. The results show that the present method is an effective method to fabricate a highly porous HA ceramic scaffolds. With increasing the ratio of slurry/wax spheres, the interconnectivity gets better and the optimal ratio of slurry/wax spheres is 1:1.2.

Key words: porous HA ceramic scaffolds, accumulated wax spheres, interconnectivity, compressive strength

CLC Number:

R318

ZHAO Jing, LI Jin-Yu, ZHI Wei, LU Xiong, JIA Zhi-Bin, WENG Jie. Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method[J]. Journal of Inorganic Materials, 2013, 28(1): 74-78.

Figures/Tables 8

Fig.1 (a) Flow chart of preparation process and (b) sketch map of moulding process for porous HA ceramic scaffold

Fig. 2 Appearance of the pore former of wax spheres

Fig. 3 XRD pattern of sintered porous HA scaffold

Fig. 4 Stereo microscope morpholegies of the porous scaffolds under different casting strengths

Table 1 Properties of porous HA ceramic scaffolds with different ratios of slurry/wax spheres

Slurry/wax spheres	Porosity/%		Shrinkage/%		Interconnected pores/μm
Slurry/wax spheres	HA-20	HA-30	HA-20	HA-30	HA-20	HA-30
1:1.0	85.5	89.0	50.3	35.6	227±91	323±72
1:1.2	85.6	90.1	50.9	35.5	277±83	346±79
1:1.4	86.8	91.4	51.8	35.3	326±93	372±95
1:1.6	87.1	91.8	52.5	35.4	390±121	404±97

Fig. 5 Stereo microscope morphologies of HA-20 (a, b) and HA-30 (c, d) scaffolds with the slurry/wax spheres ratio of 1:1 (a,c) and 1:1.6 (b,d)

Fig. 6 SEM images of typical microstructure of pore wall

Fig.7 Compressive strengths of porous HA ceramics scaffolds with different ratios of slurry/wax spheres

References 14

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Preparation and Optimization of Porous HA Ceramic Scaffolds by Wax Spheres Leaching Method

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