Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity

doi:10.3724/SP.J.1077.2011.00017

Journal of Inorganic Materials ›› 2011, Vol. 26 ›› Issue (1): 17-21.DOI: 10.3724/SP.J.1077.2011.00017

• Research Paper • Previous Articles Next Articles

Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity

GUOLai-Yang¹, ZHANG Jing-Wei¹, ZHAO Jing¹, WANGJian-Xin¹, WENG Jie¹, ZHANG Cong²

1. KeyLaboratory of Advanced Technologies of Materials, Ministry of Education, Schoolof Materials Science and Engineering, Southwest Jiaotong University, Chengdu610031, China; 2. 452nd Hospital of Chinese PLA, Chengdu 610021, China

Received:2010-02-09 Revised:2010-04-28 Published:2011-01-20 Online:2010-12-23
Supported by:
National Nature Science Foundation ofChina(30870630); Specialized Research Fund for the Doctoral Program of HigherEducation(20070613062); Science and Technology Research Foundation of SichuanProvince(2008Jy0062)

Abstract

Abstract: The pore interconnectivity isa key factor for the application of porous bioceramics as bone tissue engineeringscaffolds. Packed wax spheres were treated with dimethyl benzene and acted as theporogen for the preparation of porous ceramic scaffolds, in order to increasethe inter-sphere connectivity. The morphology, porosity, shrinkage, and thecompressive strength of the obtained ceramic scaffolds were analyzed. The cellcompatibility of the scaffolds was evaluated with Sprague-Dawley (SD) osteoblasts.The results showed that the pore interconnectivity and volumetric porosity weresignificantly increased by the dimethyl benzene treatment. Scaffolds with differentporosities had similar shrinkage. Osteoblasts migrated deeply into the centerof the porous ceramic scaffold through the interconnected pores and got normalactivity. Porous scaffolds with better interpore connectivity could provid morespace for the proliferation of osteoblasts.

Key words: porousscaffolds, particulate-leaching, interpore connectivity, bridging

CLC Number:

R318
TQ174

GUOLai-Yang, ZHANG Jing-Wei, ZHAO Jing, WANGJian-Xin, WENG Jie, ZHANG Cong. Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity[J]. Journal of Inorganic Materials, 2011, 26(1): 17-21.

References

[1] Ma P X. Biomimetic materials for tissue engineering. Advanced Drug Delivery Reviews, 2008, 60(2): 184-198.
[2] Lien S M, Ko L Y, Huang T J. Effect of pore size on ECM secretionand cell growth in gelatin scaffold for articular cartilagetissue engineering. Acta Biomaterialia,2009, 5(2): 670-679.
[3] Wang H N, Li Y B, Zuo Y, et al. Biocompatibility and osteogenesisof biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissueengineering. Biomaterials, 2007, 28(22): 3338-3348.
[4] Hutmacher D W. Scaffolds in tissue engineering boneand cartilage. Biomaterials, 2000, 21(24):2529-2543.
[5] Ma P X. Scaffolds for tissue fabrication. Materials Today, 2004, 7(5):30-40.
[6] Tadic D, Beckmann F, Schwarz K, etal. A novel method to produce hydroxyapatite objects with interconnectingporosity that avoid singtering. Biomaterials,2004, 25(16): 3335-3340
[7] Gauthier O, Bouler J M, Aguado E, et al. Macroporous biphasic calcium phosphate ceramics influence ofmacropore diameter and macroporosity percentage on bone ingrowth. Biomaterials, 1998, 19(3): 133-139.
[8] Carine W, Brigitte G, Christelle L, et al. Biomaterial surface properties modulate <>in vitro ratcalvaria osteoblasts response: roughness and or chemistry? Materials Science and Engineering C, 2008, 28(5/6): 990-1001.
[9] Ponsonnet L, Reybier K, Jaffrezic N, et al. Relationship between surface properties (roughness,wettability) of titanium and titanium alloys and cell behaviour. Materials Science and Engineering C,2003, 23(4): 551-560.
[10] Sánchez-Salcedo S, Nieto A, Vallet-Regí M. Hydroxyapatite/ β-tricalciumphosphate/agarose macroporous scaffolds for bone tissue engineering. Chemical Engineering Journal, 2008, 137(1): 62-71.
[11] Woodarda J R, Hilldore A J, Lan S K, et al. The mechanical properties and osteoconductivity ofhydroxyapatite bone scaffolds with multi-scale porosity. Biomaterials, 2007, 28(1):45-54.
[12] Zhao J, Guo L Y, Yang X B, etal. Preparation of bioactive porous HA/PCL composite scaffolds. Applied Surface Science, 2008, 255(5): 2942-2946.
[13] Boyan B D, Batzer R, Kieswetter K, et al. Titanium surface roughness alters responsiveness of MG63osteoblast-like cells to 1α, 25-(OH)₂D₃. Journal of Biomedical Materials Reseach.1998, 39(1): 77-85.
[14]Liu Y R, Qu S X, Maitz M F, et al. The effect of the major componentsof salvia miltiorrhiza bunge on bone marrow cells. Journal of Ethnopharmacology, 2007, 111(3): 573-583.

Preparation andCharacterization of Porous Scaffolds with Favourable Interpore Connectivity

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 1

Recommended Articles

Metrics

Comments