离子束辅助沉积氧化钛对改善热解碳抗凝血性能作用的初步研究

无机材料学报

离子束辅助沉积氧化钛对改善热解碳抗凝血性能作用的初步研究

陈安清; 徐德民; 王哲; 赵强; 蒋振斌

复旦大学附属中山医院心脏外科上海 200032

收稿日期:2003-08-21 修回日期:2003-09-19 出版日期:2004-09-20 网络出版日期:2004-09-20

TiO₂ Thin Film Deposited by Enhanced Ion Beam Technique to Improve Anti-coagulability of Pyrolysis Carbon Applied to Artificial Heart Valves

CHEN An-Qing; XU De-Min; WANG Zhe; ZHAO Qiang; JIANG Zhen-Bin

Department of Cardiovascular Surgery of Zhongshan Hospital; Fudan University; Shanghai 200032; China

Received:2003-08-21 Revised:2003-09-19 Published:2004-09-20 Online:2004-09-20

摘要/Abstract

摘要： 用离子束辅助沉积的方法在人工心脏瓣膜热解碳材料表面制备氧化钛薄膜,研究其对抗凝血性能的改善情况,以探索新型的人工瓣膜材料.对样本分别进行体外血小板黏附试验和动物体内试验以观察血栓形成的情况.结果表明,相比较传统的热解碳材料而言,氧化钛薄膜处理过的材料上黏附的血小板数目和聚集的血小板团数均明显减少,且血小板伪足数目亦明显减少.动物体内试验亦表明有氧化钛薄膜的样本表面形成的血栓较传统的热解碳材料要少,且没有热解碳材料表面有大量的血小板聚集和纤维蛋白形成.研究结果显示用离子束辅助沉积技术制备的氧化钛薄膜,其抗凝血性能优于目前临床应用的热解碳材料,很可能成为新一代的人工瓣膜材料.

关键词: 人工心脏瓣膜, 氧化钛薄膜, 血液相容性

Abstract: A new kind of materials applied to the artificial heart valve, rutile-TiO₂ thin film on low temperature
isotropic pyrolysis carbon (LTI-carbon) was deposited through the enhanced ion beam approach. The thrombosis on the surface of samples was observed
through platelet adhesion in vitro and animal experiments in vivo, respectively. Compared with LTI-carbon material, there is
much less platelets adhesion, aggretated and coagulated as well as deformed on the surface of the thin film. Animal experiments in vivo
also show that the amount of thrombus on the observed surface is much less than that of LTI-carbon. There are numerous platelets and
fibrin aggregated and formed on the surface of LTI-carbon, but not on the surface of the thin film. The anti-coagulability of the deposited rutile-TiO₂thin film is much better
than that of LTI-carbon traditionally used in artificial heart valves. And it also indicates that the deposited TiO₂ thin film is a new kind of promising
materials applied to artificial heart valves.

Key words: artificial heart valve, titanium oxide film, blood compatibility

中图分类号:

R318
TB43

陈安清,徐德民,王哲,赵强,蒋振斌. 离子束辅助沉积氧化钛对改善热解碳抗凝血性能作用的初步研究[J]. 无机材料学报.

CHEN An-Qing,XU De-Min,WANG Zhe,ZHAO Qiang,JIANG Zhen-Bin. TiO₂ Thin Film Deposited by Enhanced Ion Beam Technique to Improve Anti-coagulability of Pyrolysis Carbon Applied to Artificial Heart Valves[J]. Journal of Inorganic Materials.

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