多孔微晶玻璃作为药物载体材料的制备及其体外释药研究

无机材料学报

多孔微晶玻璃作为药物载体材料的制备及其体外释药研究

王德平; 黄文旵; 陈天丹

同济大学材料科学与工程学院上海 200092

收稿日期:2000-12-04 修回日期:2001-01-02 出版日期:2001-11-20 网络出版日期:2001-11-20

Preparation and in Vitro Drug Release Behavior Study of Porous Phosphate Glass Ceramic

WANG De-Ping; HUANG Wen-Hai; CHENG Tian-Dan

School of Materials Science and Engineering; Tongji University; Shanghai 200092; China

Received:2000-12-04 Revised:2001-01-02 Published:2001-11-20 Online:2001-11-20

摘要/Abstract

摘要： 应用玻璃结晶法制备了以磷酸钙为主体的多孔微晶玻璃载体材料，并以利福平作为模型药物进行了体外释药试验．研究表明该载体材料能够在高浓度水平下长期维持药物的稳定释放；研究结果还显示调节磷酸钙纤维的几何尺寸可以有效地改变载体材料的空隙率，因此有望成为一种理想的ＤＤＳ（Ｄｒｕｇｄｅｌｉｖｅｒｙｓｙｓｔｅｍ）药物控释性释放的新型无机载体材料．

关键词: 生物微晶玻璃, 药物载体, 缓释作用

Abstract: The preparation and properties of porous glass ceramic (PGC) carrier materials made from the base glass composition CaO-P₂O₅ were investigated. Rifapin (R) was used as a model drug, in vitro drug delivery anylyses of R-PGC were performed. Based on this results, the drug carrier can gradually re1ease rifapin with effective drug concentration in 1ong time. Through the adjustment of aspect ratios of calcium phosphate fiber, the porosity can be effeictely changed. So it is helpful to make the durg delivery system (DDS), and further study should be engaged.

Key words: bioglass ceramic, drug carrier, slow-release

中图分类号:

TQ171

王德平,黄文旵,陈天丹. 多孔微晶玻璃作为药物载体材料的制备及其体外释药研究[J]. 无机材料学报.

WANG De-Ping,HUANG Wen-Hai,CHENG Tian-Dan. Preparation and in Vitro Drug Release Behavior Study of Porous Phosphate Glass Ceramic[J]. Journal of Inorganic Materials.

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