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Journal of Inorganic Materials

Journal of Inorganic Materials >

2007 , Vol. 22 >Issue 1: 123 - 127

DOI: https://doi.org/10.3724/SP.J.1077.2007.00123

Research Paper

Bio-mineralization Properties of Bioglass and Effect of Ionic Products from Bioglass Dissolution on Osteoblast Functions

  • TU Jie ,
  • WANG Ying-Jun ,
  • CHEN Xiao-Feng ,
  • OU Yang-Jun ,
  • QIU Xiao-Zhong
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  • South China University of Technology 1. Institute of Biomedical Material; 2. Key Laboratory of Specially Functional Materials and Advanced Manufacturing
    Technology of Ministry of Education, Guangzhou 510640, China; 3. Department of Anatomy, Southern Medical University, Guangzhou 510515, China; 4. Key Laboratory of Tissue Construction and Detection of Guangdong, Guangzhou 510515, China

Received date: 2006-01-18

  Revised date: 2006-05-16

  Online published: 2007-01-20

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Abstract

The bio-mineralization properties of the melt-derived bioglass 45S5 and the sol-gel derived bioglass 58S and 77S in vitro were investigated. The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and ALP activity was also discussed. The results show that osteoblasts cultured with 77S conditioned DMEM show better cellular viability and ALP activity when compared to 45S5 and 58S, though the bio-mineralization of 77S shows a little worse---only HA can form from 77S when HCA can form from 45S5 and 58S. By comparing the Si concentrations in bioglass conditioned DMEM and control DMEM, it can be concluded that solutions containing high Si concentrations in certain range are mitogenic for bone cells.

Key words： bioglass; bio-mineralization; cellular viability; alkaline phosphatase

Cite this article

TU Jie , WANG Ying-Jun , CHEN Xiao-Feng , OU Yang-Jun , QIU Xiao-Zhong . Bio-mineralization Properties of Bioglass and Effect of Ionic Products from Bioglass Dissolution on Osteoblast Functions[J]. Journal of Inorganic Materials, 2007 , 22(1) : 123 -127 . DOI: 10.3724/SP.J.1077.2007.00123

References

[1] Hench L L. Science, 2002, 295: 1014--1017.
[2] Hench L L. Bioceramics, 1998, 1: 1705--1728.
[3] Rámila A, Regí M V. Biomaterials, 2001, 22: 2301--2306. [4] Burg K J, Porter S, Kellam J F. Biomaterials, 2000, 21: 2347--2359.
[5] Hench L L, Xynos I, Edgar A, et al. 无机材料学报(Journal of Inorganic Materials), 2002, 17 (5): 897--909.
[6] Xynos I, Edgar A J, Buttery L, et al. Biochem. Biophys. Res. Commun., 2000, 276 (2): 461--465.
[7] Hattar S, Asselin A, Greenspan D, et al. Biomaterials, 2005, 26: 839--848.
[8] 张梅梅, 陈晓峰, 王迎军, 等. 玻璃与搪瓷, 2003, 31 (3): 15--20.
[9] 陈晓峰, 张梅梅, 赵靖, 等. 生物医学工程学杂志, 1999, 16 (?
增刊): 25--28.
[10] Liu Xuanyong, Ding Chuanxian. Materials Letter, 2002, 57 (3): 652--655.
[11] 肖斌, 周大利, 杨为中(XIAO Bin, et al).
无机材料学报(Journal of Inorganic Materials), 2006, 21 (2): 427--432.
[12] 王传辉, 李贺军, 黄凤萍(WANG Chuan-Hui, et al). 无机材料学报(Journal of Inorganic Materials), 2005, 20 (4): 837--841.
[13] 钟吉品(ZHONG Ji-Pin). 无机材料学报(Journal of Inorganic Materials), 1995, 10 (2): 129--137.
[14] 张克从, 张乐. 晶体生长科学与技术, 第二版. 北京: 科学出版社, 1997. 221--228.
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