Research Paper

Modulation of Mixed Potassium Carboxylates on Crystallization of Calcium Oxalate Crystals in Gel System

  • LIU Yi-Ming ,
  • YUAN Huan-Xin ,
  • OUYANG Jian-Ming
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  • 1. Department of Chemistry and Chemical Engineering, Hunan Insititute of Science and Technology, Yueyang 414000, China; 2.Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China

Received date: 2006-03-14

  Revised date: 2006-05-08

  Online published: 2007-01-20

Abstract

Potassium tartrate (K2tart), potassium citrate (K_3cit) and dipotassium ethylene diamine tetraacetate (K2edta) can be used to prevent and cure calcium oxalate (CaOxa) stones. It was investigated that the modulation of the mixed potassium carboxylates of these three compounds on the crystallization of CaOxa in gel system by a double diffusion technique. The results show that the mixed carboxylates can either induce more calcium oxalate dihydrate (COD) and trihydrate (COT) crystals, or decrease the size and special surface area of calcium oxalate monohydrate (COM). For the mixture of K2edta and K3cit, the twisted COD crystals are grown. These twisted COD crystals look like the morphology of the COD grown in healthy human urine and have a less (100) crystal face, which can decrease the retention and adhesion of COD crystals on the surface of renal tubular cells. All these effect can inhibit the formation of CaOxa stones. It demonstrates that the mixed potassium carboxylates have better inhibitive effect than any of the single.

Cite this article

LIU Yi-Ming , YUAN Huan-Xin , OUYANG Jian-Ming . Modulation of Mixed Potassium Carboxylates on Crystallization of Calcium Oxalate Crystals in Gel System[J]. Journal of Inorganic Materials, 2007 , 22(1) : 75 -78 . DOI: 10.3724/SP.J.1077.2007.00075

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