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Journal of Inorganic Materials

Journal of Inorganic Materials >

2010 , Vol. 25 >Issue 1: 58 - 62

DOI: https://doi.org/10.3724/SP.J.1077.2010.00058

Research Paper

Study on the Performance of Radioactive Dysprosium Lithium Borate Glass
Mircrospheres used for Synovectomy Treatment

  • YU Jing ,
  • ZHAO Di ,
  • HUANG Wen-Hai ,
  • ZHOU Nai ,
  • WANG De-Ping ,
  • YIN Wei ,
  • CHEN Ya-Qing
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  • （1. School of Materials Science and Engineering, Tongji University, Shanghai 200092, China; 2. Institute of Isotope Research, Sinitic Academy of Atomic Energy, Beijing 102413, China; 3. The Sixth Hospital, Shanghai 200233, China）

Received date: 2009-04-21

  Revised date: 2009-05-31

  Online published: 2010-01-24

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Abstract

The radioactive dysprosium lithium borate glass (DyLB) microspheres used for synovectomy were prepared. The biodegradability and biocompatibility of theses DyLB microspheres were investigated by in-vitro and in-vivo test. The DyLB microspheres reacted nonuniformly in simulated body fluid (SBF9) with more than 53wt% of lithium being dissolved, whereas nearly all of the dysprosium (>99.997wt%) remained in the reacted microspheres, after being immersed in SBF9 at 37℃ for 7d. For three different compositions, the weight loss of DyLB microspheres was 16%－43％ when they were immersed in SBF9 for 1d; After being immersed in SBF9 for 7d, the weight loss of these DyLB microspheres was up to (25%－55%), and the precipitationdissolution reaction reached equilibrium, indicating that the DyLB microspheres were partially biodegradable in SBF9. Furthermore, the DyLB microspheres had good biocompatibility, since no tissue damage or inflammation was detected after being implanted in the liver of rat for two weeks. After being neutron activation, the radionuclide purity of radioactive DyLB microspheres was over 99.9%, which can be used for radiation synovectomy treatment in clinic.

Key words： borate glass microspheres; biodegradability; biocompatibility; radiation synovectomy

Cite this article

YU Jing , ZHAO Di , HUANG Wen-Hai , ZHOU Nai , WANG De-Ping , YIN Wei , CHEN Ya-Qing . Study on the Performance of Radioactive Dysprosium Lithium Borate Glass
Mircrospheres used for Synovectomy Treatment[J]. Journal of Inorganic Materials, 2010 , 25(1) : 58 -62 . DOI: 10.3724/SP.J.1077.2010.00058

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