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Journal of Inorganic Materials

Journal of Inorganic Materials >

2006 , Vol. 21 >Issue 6: 1467 - 1471

DOI: https://doi.org/10.3724/SP.J.1077.2006.01467

Research Paper

Damaging Effects of Nanosized TiO2 on Bel-7402 Human Liver Cancer Cell Under Photoinduce

  • XIA Chun-Hui ,
  • WANG Bai-Qi ,
  • WANG Yu ,
  • LIU Ya-Qin ,
  • XU Guang-You ,
  • WU Shan
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  • 1. Chemistry Department, Qiqihaer Medical College, Qiqihaer 161042, China;
    2. Department of Applied Chemistry, Harbin Institute of Technology, Harbin 150001, China; 3. Department of Biological Chemistry, China Medical University, Shenyang 110001, China

Received date: 2005-12-19

  Revised date: 2006-03-16

  Online published: 2006-11-20

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Abstract

The damaging effects of nanosized
TiO2 on human Bel-7402 liver cancer cell were investigated by means of HE
dye method and MTT colorimetric assay under condition of photoinduce. The
influences of nanosized TiO2 content, and irradiation time on cancer inhibition were systematically studied, and the inhibition mechanism was primarily discussed. The results show that nanosized TiO2 exhibits good inhibition effects under appropriate TiO2 concentration, and the inhibition process obeys first order reaction rule approximately; In addition, activity oxygen produced by nanosized TiO2 under illumination can react with organicmolecules in and out the cancer cell membrane, so that lead to damage cell structure, result into imbalance of Ca 2+ in the cancer cell, and induce microtubule reassembly due to expression changes of microtubule-associated protein-2, which are responsible for the apoptotic and dead cancer cells.

Key words： nanosized TiO2; photoinduced-damage; liver cancer cell; MAP-2

Cite this article

XIA Chun-Hui , WANG Bai-Qi , WANG Yu , LIU Ya-Qin , XU Guang-You , WU Shan . Damaging Effects of Nanosized TiO2 on Bel-7402 Human Liver Cancer Cell Under Photoinduce[J]. Journal of Inorganic Materials, 2006 , 21(6) : 1467 -1471 . DOI: 10.3724/SP.J.1077.2006.01467

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