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Journal of Inorganic Materials

Journal of Inorganic Materials >

2010 , Vol. 25 >Issue 5: 507 - 511

DOI: https://doi.org/10.3724/SP.J.1077.2010.00507

Research Paper

Properties of Calcium Phosphate Cement with various Concentrations of Xiangdan Injection

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  • 1. Emei campus, Southwest Jiaotong University, Emei 614202, China; 2. Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

Received date: 2009-08-31

  Revised date: 2009-11-23

  Online published: 2010-05-12

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Abstract

Effects of the concentrations of Xiangdan injection on properties of calcium phosphate cement（CPC） and the drug release rate were investigated, which would offer the theory evidence for optimizing the concentration of Xiangdan in CPC. Xiangdan and calcium hydrogen phosphate (DCPD) were mixed and dried to prepare Xiangdanloaded DCPD which was subsequently used to prepare CPCs containing various concentrations of Xiangdan. The properties of CPCs with various Xiangdan concentrations were characterized by Gilmore needles, universal material mechanical machine, Xray diffraction (XRD), Fouriertransform infrared spectrometer (FT-IR), and Scanning electron microscope (SEM). The in vitro drug release was studied. The setting time increased with increasing Xiangdan concentration in CPC, while the setting time at a concentration of or below 0.2mL/g could meet the clinic requirement. The compressive strength increased with increasing Xiangdan concentration in CPC. No significant difference in the phase component and conversion degree was observed in the hydrated CPC with and without Xiangdan. SEM tests found that the morphology of crystals changed from particles to plates with the increase of Xiangdan concentration in CPC. In the first 4h, the in vitro release of Xiangdan from CPC with a Xiangdan concentration of 0.1-0.5mL/g could satisfy with the clinic requirement. It can be concluded that both the properties of CPC and the in vitro release of Xiangdan from CPC could meet the clinical applications in the primary stage when Xiangdan concentrations were in the range of 0.1-0.2mL/g.

Key words： calcium phosphate cement; xiangdan injection; property; concentration; drug release

Cite this article

LI Mao-Hong1,2, QU Shu-Xin2, YAO Ning2,3, GUO Yue-Hua2, ZHANG Tao2, WENG Jie2 . Properties of Calcium Phosphate Cement with various Concentrations of Xiangdan Injection[J]. Journal of Inorganic Materials, 2010 , 25(5) : 507 -511 . DOI: 10.3724/SP.J.1077.2010.00507

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