Journal of Inorganic Materials >
Luminescent Properties and Cytotoxicity of CdTe Quantum Dots with Different Stabilizing Agents
Received date: 2009-08-24
Revised date: 2009-10-14
Online published: 2010-05-12
CdTe quantum dots (QDs) were prepared in aqueous phase using thioglycolic acid (TGA), L-cysteine(L-Cys), and glutathione (GSH) as stabilizing agents. The luminescent properties of CdTe QDs with different stabilizing agents were studied by using fluorescence spectra. FTIR spectra analysis demonstrates that CdTe QDs are capped with stabilizing agents through the coordination interaction between Cd2+ and S. Fluorescence spectra show that CdTe QDs with longer emission wavelength (680nm) can be synthesized more easily when L-Cys or GSH is chosen as stabilizing agents and TGA is proper to prepare highly luminescent QDs because of the effect between Cd2+ and sulfhydryl group. The MTT assay and morphology analysis of U87MG cells suggest that the QDs with different stabilizing agents are all toxic to cells. The cytotoxicity of TGAQDs is higher than that of L-Cys- and GSH- CdTe. The cell viability is only 52.6% when U87MG cells are treated with 20μg/mL of TGA-QDs for 24h.
Key words: stabilizing agents; CdTe; quantum dots; luminescence; cytotoxicity
LI Zheng-1 , 2 , HONG Yong-Xian-1 , ZHANG Guo-Xin-1 , HAN Pan-Jiang- 1 , 2 . Luminescent Properties and Cytotoxicity of CdTe Quantum Dots with Different Stabilizing Agents[J]. Journal of Inorganic Materials, 2010 , 25(5) : 495 -499 . DOI: 10.3724/SP.J.1077.2010.00495
[1]Wuister S F, Swart I, Driel F V, et al. Highly luminescent water-soluble CdTe quantum dots. Nano Lett., 2003, 3(4): 503-507.
[2]Kapitonov A M, Stupak A P, Gaponenko S V, et al. Luminescence properties of thiol-stabilized CdTe nanocrystals. J. Phys. Chem. B, 1999, 103(46): 10109-10113.
[3]Wang S P, Mamedova N, Kotov N A, et al. Antigen/antibody immunocomplex from CdTe nanoparticle bioconjugates. Nano Lett., 2002, 2(8): 817-822.
[4]陈良冬,李 雁,袁宏银,等.量子点在肿瘤研究中的应用. 癌症, 2006, 25(5): 651- 656.
[5]徐万帮,汪勇先,许荣辉,等(XU Wan-Bang, et al). Ⅱ-Ⅵ型量子点的制备、修饰及其生物应用. 无机材料学报(Journal of Inorganic Materials), 2006, 21(5): 322-328.
[6]Gaponik N, Talapin D V, Rogach A L, et al. Thiol-capping of CdTe nanocrystals: An alternative to organometallic synthetic routes. J. Phys. Chem. B, 2002, 106(29): 7177-7185.
[7]唐爱伟, 滕 枫, 高银浩,等(TANG Ai-Wei, et al). 水相中CdSe与核/壳CdSe/CdS量子点的制备与发光特性研究. 无机材料学报(Journal of Inorganic Materials), 2006, 21(2): 322-328.
[8]刘明贤, 孙 颖, 甘礼华, 等(LIU Ming-Xian, et al).静电自组装制备CdTe量子点纳米薄膜.无机材料学报(Journal of Inorganic Materials), 2008, 23(3): 557-561.
[9]Hoshino A, Fujioka K, Oku T, et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett., 2004, 4(11): 2163-2169.
[10]Guo J, Yang W L, Wang C C. Systematic study of the photoluminescence dependence of thiol-capped CdTe nanocrystals on the reaction conditions. J. Phys. Chem. B, 2005, 109(37): 17467-17473.
[11]Peng X G, Wickham J, Alivisatos A P. Kinetics of Ⅱ-Ⅵ and Ⅲ-Ⅴ colloidal semiconductor nanocrystal growth: “Focusing” of size distributions. J. Am. Chem. Soc., 1998, 120(21): 5343-5344.
[12]侯绍英, 张 岭, 吴 坤,等. 巯基乙酸对孕酮诱导爪蟾卵母细胞体外成熟过程中MAPK和MPF激酶活性的影响.癌变·畸变·突变, 2008, 20(2): 107-110.
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