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Journal of Inorganic Materials

Journal of Inorganic Materials >

2010 , Vol. 15 >Issue 2: 211 - 215

DOI: https://doi.org/10.3724/SP.J.1077.2010.00211

Research Paper

Study on Cytocompatability and Animal Implantation Test of Foam SiC

  • WU Lin ,
  • XU Xing-Xiang ,
  • WANG Lu-Zeng ,
  • RONG Xiao-Fang ,
  • TIAN Chong ,
  • ZHANG Jin-Song
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  • (1. Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang 110002, China; 2. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; 3. Animal Test Centre, China Medical University, Shenyang 110001, China)

Received date: 2009-08-17

  Revised date: 2009-10-13

  Online published: 2010-02-20

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Abstract

Foam SiC was prepared by macromolecule pyrogenation combined with reaction bonding method.The osteoblast-like cells MG63 were seeded and cultured in vitro on the foam SiC and observed under both SEM and TEM to further evaluate the cytocompatability of this novel material. The feasibility of the foam SiC as a bone replacement material for clinical treatment was also studied by establishing an animal model for repairing mandibular criticalsized defects in rabbits, and by using general observation, histological observation and bone histomorphometry.The results show that MG63 cells attach and grow well on the surface of the foam SiC, which indicates that the foam SiC is non-toxic and possesses good cytocompatibility. The 26 tested rabbits are all in healthy conditions and the wounds are healed completely. The different degree of osteogenesis is observed on both periphery and inner mesh of the foam SiC at each time point, and the foam SiC shows no adverse effect to the process of bone repair. It is found that both the rate of tetracycline fluorescence labeling and the new bone area on the foam SiC are lower than those of hydroxyapatite (HA) after 4w implantation, but there are no statistical differences after both 8w and 24w implantations, indicating that the foam SiC should be similar to HA in osteo-conduction ability judging from the long-term repair effect to mandibular defects.

Key words： foam SiC; bone replacement material; cell; animal implantation

Cite this article

WU Lin , XU Xing-Xiang , WANG Lu-Zeng , RONG Xiao-Fang , TIAN Chong , ZHANG Jin-Song . Study on Cytocompatability and Animal Implantation Test of Foam SiC[J]. Journal of Inorganic Materials, 2010 , 15(2) : 211 -215 . DOI: 10.3724/SP.J.1077.2010.00211

References

［1］王 伟, 邱蔚六, 袁文化, 等. 应用国产消旋聚乳酸载体复合rhBMP-2和hTGF-β1修复兔下颌骨缺损.中国口腔颌面外科杂志, 2003, 1(3): 166-171.

［2］Cerroni L, Filocamo R, Fabbri M, et al. Growth of osteoblastlike cells on porous hydroxyapatite ceramics: an in vitro study. Biomolecular Engineering, 2002, 19(2-6): 119-124.

［3］包崇云, 张兴栋. 磷酸钙生物材料固有骨诱导性的研究现状与展望.生物医学工程学杂志, 2006, 23(2): 442-445.

［4］TIAN Chong, ZHANG Jinsong, CAO Xiaoming. High strength silicon carbide foams and their deformation behavior. Mater. Sci. Technol., 2006, 22(2): 269-272.

［5］陈治清. 口腔材料学, 3版.北京:人民卫生出版社, 2003: 108-115.

［6］吴 琳, 徐兴祥, 李 波, 等. 泡沫碳化硅的生物相容性.材料研究学报, 2008, 22(1): 58-62.

［7］Schmitz J P, Hollinger J O. The critical size defect as an experimental model for craniomandibulofacial Nonunions. Clini. Orthop. Rel. Res., 1986, 205: 299-308.

［8］荣小芳, 吴 琳, 杨晓东, 等. 兔下颌骨临界骨缺损人工材料植入实验动物模型的建立.中国医科大学学报, 2008, 37(1): 62-64.

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