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Journal of Inorganic Materials

Journal of Inorganic Materials >

2010 , Vol. 25 >Issue 1: 53 - 57

DOI: https://doi.org/10.3724/SP.J.1077.2010.00053

Research Paper

Study on Hollow Hydroxyapaptite Microspheres Prepared by a Borate Glass Conversion Process

  • YAO Ai-Hua ,
  • AI Fan-Rong ,
  • LIU Xin ,
  • WANG De-Ping ,
  • HUANG Wen-Hai
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  • (1. School of Materials Science and Engineering, Tongji University, Shanghai 200092, China; 2. Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, Tongji University, Shanghai 200092, China)

Received date: 2009-04-08

  Revised date: 2009-06-05

  Online published: 2010-01-24

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Abstract

Hollow hydroxappatite (HAP) microspheres consisting of a hollow core and a porous shell were prepared by a Li-Ca-B glass conversion process. The phase composition, morphology and pore structure on the shell wall were investigated using XRD, SEM and BET. The results showed that the asprepared microspheres possessed good internal hollow structure. The shell wall of the microsphere was made up of HAP crystals fully. After heattreated at 600℃ for 2h, the compressive strength of the microsphere was determined to be (2.1±0.6)MPa, and the porosity and pore size of the shell wall were 85% and 60nm, respectively. Furthermore, the formation mechanism of the hollow HAP microsphere was also suggested. In phosphate solution, Ca-P-OH hydrate was in-situ formed on the surface of the glass and precipitated in the position initially occupied by Ca2+, while the pores were formed in the position initially occupied by Li+ and B3+. These hollow HAP microspheres may be useful for drug delivery.

Key words： hydroxyapatite; hollow microsphere; borate glass; drug delivery

Cite this article

YAO Ai-Hua , AI Fan-Rong , LIU Xin , WANG De-Ping , HUANG Wen-Hai . Study on Hollow Hydroxyapaptite Microspheres Prepared by a Borate Glass Conversion Process[J]. Journal of Inorganic Materials, 2010 , 25(1) : 53 -57 . DOI: 10.3724/SP.J.1077.2010.00053

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