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Journal of Inorganic Materials

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2009 , Vol. 24 >Issue 1: 166 - 170

DOI: https://doi.org/10.3724/SP.J.1077.2009.00166

Research Paper

Preparation and Drug Release Properties of Nanostructured CaCO3 Porous Hollow Microspheres

  • LI Liang ,
  • ZHU Ying-Jie ,
  • CAO Shao-Wen ,
  • MA Ming-Yan
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  • State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Received date: 2008-05-04

  Revised date: 2008-06-03

  Online published: 2009-01-20

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Abstract

CaCO3 nanostructured porous hollow microspheres were synthesized using CaCl2, Na2CO3, SDS in aqueous solution at room temperature. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscope (TEM) and scanning electron microscope (SEM). The drug loading and release properties of CaCO3 nanostructured porous hollow microspheres were investigated in artificial gastric juice (pH＝1.2) and simulated intestinal fluid (pH＝7.4). Ibuprofen (IBU) was used as a model drug. The drug delivery system constructed by IBU/CaCO3 porous hollow microspheres exhibits high drug loading capacity and good drug release property. The IBU loading amount reaches 195mg/g and its release time can last for more than 53h. In comparison, the IBU loading amount reaches 130mg/g in thermally treated CaCO3 hollow microspheres in which SDS is eliminated, and the drug release time can reach 40h when IBU release percentage is 100%. The produced CaCO3 nanostructured porous hollow microspheres have the potential application in the sustained drug delivery.

Key words： CaCO3; nanostructure; hollow sphere; drug delivery

Cite this article

LI Liang , ZHU Ying-Jie , CAO Shao-Wen , MA Ming-Yan . Preparation and Drug Release Properties of Nanostructured CaCO3 Porous Hollow Microspheres[J]. Journal of Inorganic Materials, 2009 , 24(1) : 166 -170 . DOI: 10.3724/SP.J.1077.2009.00166

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