A biodegradable silica-based xerogel with nano-scale mesopores was synthesized by using improved sol-gel process, and its hemostatic properties were investigated. The phase state, chemical structure, surface morphology, specific surface areas and mesoporous structure of the synthesized silica-based xerogels were measured systemically by means of X-ray diffraction (XRD), infrared spectrum (FTIR), transmission electron microscope (TEM), and N2 adsoption-desoption (BET) techniques, respectively. The effects of the silica-based xerogel on intrinsic and extrinsic blood clotting systems were examined through the activated partial thromboplastin time (APTT) and prothrombin time (PT) tests in ~vitro, respectively. The hemostatic performance of the prepared silica-based xerogel was evaluated at the rabbit’s ear side veins compared with a traditional hemostatic dressing (Yunnan Baiyao). The results reveal that the non-crystalline silica-based xerogel with 901.17m2/g specific surface areas and 3.255nm in apertures is obtained after calcining at 600℃. The silica-based xerogel facilitates both of the intrinsic and extrinsic clotting activities significantly. The silica-based xerogel has good hemostatic effect on the rabbit’s ear side veins which is better than that of the Yunnan Baiyao.
LI Xiao-Sheng
,
LIU Chang-Sheng
,
YUAN Yuan
,
WANG Li-Jun
,
WANG Qiu-Yun
. Preparation and Hemostatic Properties of Mesoporous Silica-based Xerogels[J]. Journal of Inorganic Materials, 2008
, 23(2)
: 327
-331
.
DOI: 10.3724/SP.J.1077.2008.00327
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