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Journal of Inorganic Materials

Journal of Inorganic Materials >

2009 , Vol. 24 >Issue 5: 967 - 972

DOI: https://doi.org/10.3724/SP.J.1077.2009.00967

Research Paper

High Temperature Polyol Synthesis of Superparamagnetic CoFe2O4
Nanoparticles for Magnetic Resonance Imaging Contrast Agents

  • CHEN Jin
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  • (Institute of Chemical Material, China Academy of Engineering Physics, Mianyang 621900, China)

Received date: 2008-12-16

  Revised date: 2009-02-25

  Online published: 2009-09-20

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Abstract

The superparamagnetic CoFe2O4 nanoparticles with core size of 510nm were prepared by high temperature polyol process using FeCl3·6H2O, CoCl2·6H2O and HOOC-PEG-COOH as reactants. The samples had good monodispersibility in aqueous solution. Moreover, the influences of reaction conditions such as varieties of modification agents and their amounts, reaction temperature and time on the size, dispersibility and magnetic properties of CoFe2O4 nanoparticles were investigated. The results indicate that choosing the modification agent with strong polar group, increasing the amount of modification agent, elevating reaction temperature and extending reaction time are beneficial to obtain samples with larger particle size, better waterdispersibility and narrower size distribution. The optimum reaction condition is determined as follows, the weight ratio of metal source to HOOC-PEG-COOH is 1∶10, reaction temperature is 210-220℃ and reaction time is 2h. Magnetic analysis shows that all the samples manifest a well-defined superparamagnetic behavior at room temperature. The larger the particle sizeis is, the higher saturation magnetizationis is.

Key words： high temperature polyol process; superparamagnetic CoFe2O4 nanoparticles; magnetic resonance imaging contrast agents

Cite this article

CHEN Jin . High Temperature Polyol Synthesis of Superparamagnetic CoFe2O4
Nanoparticles for Magnetic Resonance Imaging Contrast Agents[J]. Journal of Inorganic Materials, 2009 , 24(5) : 967 -972 . DOI: 10.3724/SP.J.1077.2009.00967

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