Abstract: A new kind of materials applied to the artificial heart valve, rutile-TiO₂ thin film on low temperature
isotropic pyrolysis carbon (LTI-carbon) was deposited through the enhanced ion beam approach. The thrombosis on the surface of samples was observed
through platelet adhesion in vitro and animal experiments in vivo, respectively. Compared with LTI-carbon material, there is
much less platelets adhesion, aggretated and coagulated as well as deformed on the surface of the thin film. Animal experiments in vivo
also show that the amount of thrombus on the observed surface is much less than that of LTI-carbon. There are numerous platelets and
fibrin aggregated and formed on the surface of LTI-carbon, but not on the surface of the thin film. The anti-coagulability of the deposited rutile-TiO₂ thin film is much better
than that of LTI-carbon traditionally used in artificial heart valves. And it also indicates that the deposited TiO₂ thin film is a new kind of promising
materials applied to artificial heart valves.

Key words: artificial heart valve, titanium oxide film, blood compatibility