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2009 , Vol. 24 >Issue 3: 480 - 484

DOI: https://doi.org/10.3724/SP.J.1077.2009.00480

研究论文

多孔Nano-dHA/PLA/BCP复合支架的制备及性能研究

  • 季金苟 ,
  • 李 曦 ,
  • 周治国 ,
  • 胡承波 ,
  • 夏之宁 ,
  • 黄 锐
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  • 1. 重庆大学 化学化工学院， 重庆 400044； 2. 重庆文理学院 化学与环境科学系， 重庆 402168； 3. 重庆大学 生物工程学院， 重庆 400044

收稿日期: 2008-09-11

  修回日期: 2008-11-12

  网络出版日期: 2009-05-20

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Preparation and Characterization of Porous Nano-dHA/PLA/BCP Scaffold

  • JI Jin-Gou ,
  • LI Xi ,
  • ZHOU Zhi-Guo ,
  • HU Cheng-Bo ,
  • XIA Zhi-Ning ,
  • HUANG Rui
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  • 1. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044,China; 2. Department of Chemistry and Environment Science, Chongqing University of Arts and Science, Chongqing 402168, China; 3. College of Bioengineer, Chongqing University, Chongqing 400044, China

Received date: 2008-09-11

  Revised date: 2008-11-12

  Online published: 2009-05-20

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摘要

为改善常规的多孔聚乳酸/双相钙磷陶瓷(PLA/BCP)支架表面亲水性不佳及降解时呈酸性等不足，采用马弗炉烧结制备的BCP多孔支架浸入纳米缺钙羟基磷灰石/聚乳酸(nano-dHA/PLA)混悬液后，真空干燥得到多孔纳米缺钙羟基磷灰石/聚乳酸/双相钙磷陶瓷(nano-dHA/PLA/BCP)复合支架，利用万能测试机测试支架抗压强度，阿基米德法测定支架孔隙率，扫描电子显微镜(SEM)观察支架表面形貌，并对其保水率和体外降解过程中pH值的变化情况等进行了研究. 结果表明：多孔nanodHA/PLA/BCP复合支架表面粗糙，保水率和强度均有较大提高，在磷酸盐缓冲液（PBS）浸泡过程中pH值下降较慢，在模拟体液（SBF）中浸泡1个月后发现有较多的类骨磷灰石形成.

关键词： 纳米缺钙羟基磷灰石; 聚乳酸; 双相磷酸钙陶瓷; 支架

本文引用格式

季金苟 , 李 曦 , 周治国 , 胡承波 , 夏之宁 , 黄 锐 . 多孔Nano-dHA/PLA/BCP复合支架的制备及性能研究[J]. 无机材料学报, 2009 , 24(3) : 480 -484 . DOI: 10.3724/SP.J.1077.2009.00480

Abstract

To improve the hydrophilicity and to avoid sharp pH decrease during the degradation of polylactic acid/biphasic calcium phosphate ceramics (PLA/BCP) scaffold in solution, nano calcium deficient hydroxyapatite/polylactic acid/biphasic calcium phosphate (nano-dHA/PLA/BCP) scaffold was prepared by immersing assintered porous BCP scaffold in nano-dHA/PLA mixed solution followed by vacuum drying. The compressive strength of samples was measured by universal test machine. The porosity percentage of samples was investigated by Archimedes method. The surfaces of samples were analyzed by scanning electron microscope (SEM). The waterretention rate and pH value change of the samples incubating in phosphate buffered solution (PBS) were also studied. The results show that the compressive strength and waterretention rate of the nanodHA/PLA/BCP scaffold with rougher surface are improved. The pH decrease rate of nano-dHA/PLA/BCP scaffold is slower than that of PLA/BCP scaffolds incubating in PBS, and the surfaces have more bone-like apatite formation when incubating in simulated body fluid (SBF).

Key words： nano calcium deficient hydroxyapatite; polylactic acid; biphasic calcium phosphate ceramics; scaffold

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