研究论文

α-磷酸三钙水解法修复牙釉质龋

  • 马 英 ,
  • 李思维 ,
  • 冯祖德
展开
  • 厦门大学 材料学院, 厦门 361005

收稿日期: 2008-05-26

  修回日期: 2008-07-11

  网络出版日期: 2009-03-20

Restoration of Tooth Enamel Caries by Hydrolysis of α-TCP

  • MA Ying ,
  • LI Si-Wei ,
  • FENG Zu-De
Expand
  • College of Materials, Xiamen University, Xiamen 361005, China

Received date: 2008-05-26

  Revised date: 2008-07-11

  Online published: 2009-03-20

摘要

采用α-磷酸三钙(α-TCP)水解法在牙釉质表面制备羟基磷灰石(HA)涂层,并用XRD、SEM、TEM、显微硬度仪和自制的牙刷磨耗试验机对涂层的结构和性能进行表征. 采用L929细胞对α-TCP水解液进行细胞毒性评价. 结果显示:α-TCP在37℃条件下水解6h,即可在牙釉质表面得到厚度约20μm的HA涂层,此涂层与牙釉质表面结合紧密,涂层的硬度与正常牙釉质无明显的差异,并且具有良好的耐磨性. 该方法反应条件温和、简便、安全、有效,有望应用于龋病预防和早期釉质龋治疗.

本文引用格式

马 英 , 李思维 , 冯祖德 . α-磷酸三钙水解法修复牙釉质龋[J]. 无机材料学报, 2009 , 24(2) : 275 -279 . DOI: 10.3724/SP.J.1077.2009.00275

Abstract

A novel method was developed to grow hydroxyapatite (HA) coatings on the surface of enamel. The coatings were formed by hydrolysis of α-TCP for 6h at 37℃. The detailed characterizations of the microstructure and mechanical properties of the coatings, and cytotoxicity of α-TCP hydrolysis solution were performed. SEM and TEM analysis show that the HA coatings, approximate 20μm in thickness grow perpendicularly to the enamel surface, contacting well to the surface of enamel. Vickers microhardness and wearresistance tests indicate that there is no statistical significant difference of the hardeness and wearresistance between the coatings and healthy natural enamel. The grade of cytotoxicity of α-TCP hydrolysis solution is I grade, satisfying the relevant criterion on biomaterials. The study suggests that the hydrolysis of α-TCP is a promising method to effectively and conveniently restore and prevent early enamel caries.

参考文献

[1]于世凤,高 岩. 口腔组织学与病理学,第一版. 北京:北京大学医学出版社,2005.
[2]李 刚. 现代口腔预防医学研究,第一版. 西安:陕西科技出版社,1996.
[3]MertzFairhurst E J,Richards E E,Williams J E,et al. Am. J. Dent.,1992,5(1):5-10.
[4]Tyas M J,Anusavice K J,Frencken J E,et al. Int. Dent. J.,2000,50(1):1-12.
[5]Kidd E A M,Joyston-Bechal S,Beighton D. Caries. Res.,1993,27(5):402-408.
[6]Raskin A,Michotte-Theall B,Vreven J,et al. J. Dent.,1999,27(1):13-19.
[7]Busch S. Angew. Chem. Int. Ed., 2004,43(11):1428-1431.
[8]Yamagishi K,Onmua K,Suzuki T,et al. Nature,2005,433(24):819-819.
[9]Onmua K,Yamagishi K,Oyane A. J. Cryst. Growth,2005,282(1-2):199-207.
[10]He L Z,Feng Z D. Mater. Lett.,2007,61(18):3923-3926.
[11]何立志. 牙采由质表面原位修复涂层制备与表征. 厦门大学硕士论文,2007.
[12]马 莉. 口腔解剖生理学,第一版. 北京:人民卫生出版社,2003.
[13]Orams H J,Phakey P P,Rachinger W A,et al. Nature,1974,252(5484):584-585.
[14]Wang L J, Tang R K, Bonstein T, et al. J. Phys. Chem. B, 2005, 109(2):999-1005.
[15]Staffanou R S,Hembree J H,Rivers J A,et al. J. Prosthet. Dent.,1985,53(3):309-310.
[16]唐立辉,陈 萍,胡公诚. 医疗卫生装备, 2003,(10):54-54.
[17]徐钢梅,张彩霞,宁 丽. 中华口腔医学杂志, 2001,36(3):189-192.
[18]樊明文,边 专. 龋病学:疾病及其临床处理,第一版. 北京:人民卫生出版社,2006.
文章导航

/