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无机材料学报

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2009 , Vol. 24 >Issue 2: 280 - 284

DOI: https://doi.org/10.3724/SP.J.1077.2009.00280

研究论文

有机泡沫浸渍法制备多孔生物玻璃支架的研究

  • 谢 林 ,
  • 陈晓峰 ,
  • 赵娜如 ,
  • 郭常亮
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  • 华南理工大学1. 材料学院 生物材料研究所； 2. 特种功能材料教育部重点实验室， 广州 510640

收稿日期: 2008-07-09

  修回日期: 2008-08-27

  网络出版日期: 2009-03-20

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Study on Porous Bioglass Scaffold Prepared by Dipping with Polymer Foams

  • XIE Lin ,
  • CHEN Xiao-Feng ,
  • ZHAO Na-Ru ,
  • GUO Chang-Liang
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  • 1.Biomaterials Research Institute, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China; 2.The Key Laboratory of Specially Functional Materials, Ministry of Education, Guangzhou 510640, China

Received date: 2008-07-09

  Revised date: 2008-08-27

  Online published: 2009-03-20

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摘要

选用58S生物活性玻璃粉体为原料，利用预先处理过的聚氨酯泡沫作为模板，制备了一种孔隙率高, 贯通性好，孔径可控的生物玻璃多孔支架. 并通过排水法、X射线衍射（XRD）、扫描电子显微镜（SEM）及傅里叶红外光谱（FTIR）等方法研究和表征了多孔支架的显气孔率、晶相组成、显微形貌和生物活性. 结果表明，浸料一次所得支架的显气孔率为93%左右，浸料二次下降为80%左右；在SBF溶液中，随着时间的延长，材料表面最初形成的颗粒状钙磷化合物逐渐矿化生成叶片状碳酸羟基磷灰石(HCA)层，表明该材料恒温37℃时具有较好的生物矿化性能和生物活性.

关键词： 生物活性玻璃; 有机泡沫浸渍法; 多孔支架; 碳酸羟基磷灰石

本文引用格式

谢 林 , 陈晓峰 , 赵娜如 , 郭常亮 . 有机泡沫浸渍法制备多孔生物玻璃支架的研究[J]. 无机材料学报, 2009 , 24(2) : 280 -284 . DOI: 10.3724/SP.J.1077.2009.00280

Abstract

The porous bioglass scaffolds with high porosity and interconnectivity and controllable pore size were prepared by using the powder of sol-gel derived bioactive glass-58S as the material and the pre-produced polymer foam as the template. The apparent porosity, crystalline phases, micromorphologies and bioactivity were investigated by using Archimedes drainage method, X-ray Diffraction (XRD), Scan emission Microscope (SEM) and Fourier Transform Infrared Spectroscope (FTIR) techniques. The results show that the apparent porosity of the porous scaffolds can reach about 93% when the materials are dipped once, while the apparent porosity decreases to 80% after dipped twice. The originally formed amorphousphosphorus compounds on the surface of samples are mineralized to hydroxyl-carbonate-apatite (HCA) with increasing dipping time in the SBF solution as the reaction progressed. So it can be concluded that this kind of material has good biomineralization property and bioactivity in SBF solution at the constant temperature of 37℃.

Key words： bioactive glass; organic foam impregnation; porous scaffold; hydroxyl-carbonate-apatite (HCA)

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