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无机材料学报

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2021 , Vol. 36 >Issue 5: 552 - 560

DOI: https://doi.org/10.15541/jim20200395

研究快报

高强度羟基磷灰石纳米陶瓷的构建及其促成骨细胞活性研究

  • 吴永豪 ,
  • 李向锋 ,
  • 朱向东 ,
  • 张兴栋
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  • 四川大学 国家生物医学材料工程技术研究中心, 成都 610064
吴永豪(1990-), 男, 博士研究生. E-mail:hpu11wyh@163.com
朱向东, 研究员. E-mail: zhu_xd1973@scu.edu.cn

收稿日期: 2020-07-14

  修回日期: 2020-08-08

  网络出版日期: 2020-08-15

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Construction of Hydroxyapatite Nanoceramics with High Mechanical Strength and Efficiency in Promoting the Spreading and Viability of Osteoblasts

  • Yonghao WU ,
  • Xiangfeng LI ,
  • Xiangdong ZHU ,
  • Xingdong ZHANG
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  • National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
WU Yonghao(1990-), male, PhD candidate. E-mail:hpu11wyh@163.com
ZHU Xiangdong, professor. E-mail: zhu_xd1973@scu.edu.cn

Received date: 2020-07-14

  Revised date: 2020-08-08

  Online published: 2020-08-15

Supported by

National Key Research and Development Program of China(2016YFC1102000);National Key Research and Development Program of China(2016YFC1102003);Sichuan Science and Technology Innovation Team of China(2019JDTD0008)

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摘要

本研究旨在研究羟基磷灰石(HA)前驱粉体与所制备陶瓷之间的关系, 制备具有优良力学性能及成骨活性的HA纳米陶瓷。采用三种HA前驱粉体, 即40 ℃合成的HA-40粉体、以PEG为模板40 ℃合成的HA-40PEG粉体和80 ℃合成的HA-80粉体, 系统研究了前驱粉体对陶瓷性能的影响。结果显示, HA-40、HA-40PEG和HA-80粉体制备的陶瓷晶粒尺寸分别为(217.87±57.53)、(123.22±20.16)和(316.65±68.91) nm, 表明HA-40PEG有利于HA纳米陶瓷的制备。烧结得到的HA-40PEG纳米晶陶瓷表现出良好的力学性能, 与另外两种亚微米晶陶瓷(HA-40和HA-80)相比, 其抗压强度更高(~300 MPa)。细胞研究结果显示, HA-40PEG比HA-40和HA-80更能促进MC3T3-E1前成骨细胞的铺展和增殖。由此可知, 前驱粉体合成是影响HA陶瓷性能的关键因素, 纳米晶构建有利于同时提高其力学性能和生物学性能。

关键词： 羟基磷灰石; 纳米陶瓷; 前驱粉体; 致密度; 细胞活力

本文引用格式

吴永豪 , 李向锋 , 朱向东 , 张兴栋 . 高强度羟基磷灰石纳米陶瓷的构建及其促成骨细胞活性研究[J]. 无机材料学报, 2021 , 36(5) : 552 -560 . DOI: 10.15541/jim20200395

Abstract

The present study focuses on the construction of HA nanoceramics with excellent mechanical property and osteogenic activity, and the correlation between HA precursor powders and resulting ceramics. Three precursor powders were used, i.e. HA-40 synthesized at 40 ℃, HA-40PEG synthesized at 40 ℃ with PEG as a template, and HA-80 synthesized at 80 ℃. The results showed that grain sizes of three HA ceramics prepared by HA-40, HA-40PEG, and HA-80 precursors were (217.87±57.53), (123.22±20.16), and (316.65±68.91) nm, respectively. It demonstrated that compared with HA-40 and HA-80, HA-40PEG was more beneficial for fabricating HA nanoceramics. Among three resulting ceramics, HA-40PEG displayed the highest comprehensive strength (~300 MPa). In addition, the nano-scale HA-40PEG ceramics promoted better cell spreading and proliferation than those of submicro-scale HA-40 and HA-80 ceramics. These findings suggest that the preparation of HA precursor powders plays an important role in fabricating HA nanoceramics with simultaneous improvement of mechanical and biological properties.

Key words： hydroxyapatite; nanoceramics; initial powder; density; cellular viability

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