不同表面特征的多孔钛与皮下软组织间生物力学性质的研究

无机材料学报

不同表面特征的多孔钛与皮下软组织间生物力学性质的研究

吴尧, 李虎, 邓春林, 杨帮成, 张兴栋

四川大学生物材料工程研究中心, 成都10064

收稿日期:2003-12-01 修回日期:2004-01-12 出版日期:2005-01-20 网络出版日期:2005-01-20

Biomechanical Properties of Porous Titanium with Different Surface Characteristics Used for Soft-tissue Anchorage

WU Yao, LI Hu, DENG Chun-Lin, YANG Bang-Cheng, ZHANG Xing-Dong

Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China

Received:2003-12-01 Revised:2004-01-12 Published:2005-01-20 Online:2005-01-20

摘要/Abstract

摘要： 为解决经皮器械长期生物密封问题, 选择具有三维支架结构和合适的表面微孔多孔钛作为其皮下固定材料, 表面预沉积一层类骨磷灰石, 空白样品作为对照, 皮下植入兔子的背部. 术后40天和70天对样品与周围软组织间的结合强度进行测定, 并对断口处组织与材料间的结合形貌和区域成分进行分析. 结果表明, 随着时间的延长, 不同表面特征的材料与组织的结合强度都不断增大; 表面具有类骨磷灰石层的样品无论是结合强度还是结合形态都优于空白样品, 涂层样品40天时与组织的结合强度几乎与对照样品70天时与组织的结合强度相当. 说明类骨磷灰石层在体内有利于较早形成活跃的细胞材料表面, 有助于皮下结缔组织的长入以及与材料表面的牢固结合.

关键词: 多孔钛, 类骨磷灰石, 拉脱强度, 皮下固定

Abstract: In order to resolve the biological sealing of the percutaneous devices for a long time, porous titanium with three-dimensioned scaffold and suitable surface micropores were chosen for
fixation the subcutaneous soft tissues. Bone-like apatite was firstly precipitated on the surface of the porous Ti in vitro, and the bare surface
as control. All of the samples were implanted into the back of the rabbits subcutaneously. At 40 days and 70 days postoperation, the samples with the
surrounding soft tissues were harvested and experienced biomechanical tensile testing. After that, the tensile testing sections were observed by SEM-EDX
to analyze the situations of the tissues contacted with the different surface of the materials. The results demonstrate that all of tensile strength
of the bone-like apatite coated porous titanium is bigger than that of the control group, and the bonding state at the interface of the materials/tissue
is firmer than that of the control. When the samples implanted in~ vivo, the bone-like apatite coating precipitated in advance in~ vitro is efficient to the formation of the active cell/materials
interface, which is beneficial for the ingrowth of the fibrous tissue and formation of the tight bonding between the tissues and materials.

Key words: porous titanium, bone-like apatite, tensile strength, subcutaneous fixation

中图分类号:

Q819

吴尧,李虎,邓春林,杨帮成,张兴栋. 不同表面特征的多孔钛与皮下软组织间生物力学性质的研究[J]. 无机材料学报.

WU Yao,LI Hu,DENG Chun-Lin,YANG Bang-Cheng,ZHANG Xing-Dong. Biomechanical Properties of Porous Titanium with Different Surface Characteristics Used for Soft-tissue Anchorage[J]. Journal of Inorganic Materials.

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