交替循环浸泡在TiO2纳米管管内填充类骨磷灰石

doi:10.3724/SP.J.1077.2011.00078

无机材料学报 ›› 2011, Vol. 26 ›› Issue (1): 78-84.DOI: 10.3724/SP.J.1077.2011.00078 CSTR: 32189.14.SP.J.1077.2011.00078

交替循环浸泡在TiO₂纳米管管内填充类骨磷灰石

俞佳,肖秀峰, 梁建鹤,刘榕芳, 王春燕,毛丹

福建师范大学化学与材料学院, 福州 350007

收稿日期:2010-07-14 修回日期:2010-09-08 出版日期:2011-01-20 网络出版日期:2010-12-23
作者简介:俞佳(1986-), 女, 硕士研究生. E-mail: xiaoyu8742@163.com
基金资助:
国家自然科学基金(50970887;30600149); 卫生部科学研究基金(WKJ 2008-02-037); 教育部重点项目(209061); 福建省纳米材料重点实验室基金(NM10-03)

Filling TiO₂Nanotubes with Biological Apatite by Alternative Loop Immersion Method

YU Jia,XIAO Xiu-Feng, LIANG Jian-He,LIU Rong-Fang, WANG Chun-Yan,MAO Dan

College ofChemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China

Received:2010-07-14 Revised:2010-09-08 Published:2011-01-20 Online:2010-12-23
Supported by:
NationalNatural Science Foundation of China (50970887, 30600149); Research Foundationfrom Ministry of Health of China (WKJ 2008-02-037); Research Foundation fromMinistry of China (209061); Science Foundation from Laboratory of Nanomaterialsof Fujian Province (NM10-03)

摘要/Abstract

摘要： 采用“交替循环浸泡法(ALIM)”在TiO₂纳米管管内填充类骨磷灰石, 使磷灰石涂层由层状结构变为嵌入式结构, 并考察填充量与TiO₂纳米管结构间的关系, 通过模拟体液浸泡实验评价其生物活性. 结果表明, 甘油体系(60V电压)中制备的纳米管填充效果最好; 无定型的TiO₂纳米管相比锐钛矿相的TiO₂纳米管更能诱导类骨磷灰石的填充; 采用ALIM于TiO₂纳米管上填充类骨磷灰石可大大提高其生物活性.

关键词: TiO₂纳米管, 交替循环浸泡, 填充, 类骨磷灰石

Abstract: A vertically aligned TiO₂ nanotube array was fabricated on the surfaceof titanium substrate in fluoride-containing electrolyes by anodization. Alternative Loop Immersion Method(ALIM) was investigated to fill TiO₂ nanotubes with the biologicalapatite in the saturated solution of Ca(OH)₂ and 0.02 mol/L (NH₄)₂HPO₄.In this way, the structure of the apatite-coating on the Ti substrate waschanged for solving the problem of coating shedding well. And the amount ofsynthetic apatite formed by ALIM was quantified according to key tubeproperties such as the tube diameter, the layer thickness, the crystalstructure (amorphous or anatase), <>etc. The effect of filling biologicalapatite of TiO₂ nanotubes fabricated in glycerol-based electrolyteat 60V is the best. And the rate of inducing biological apatite on amorphous TiO₂nanotubes with the treatment of ALIM is better than that of anatase TiO₂nanotubes. Mineralization <>in vitro experiments indicates that TiO₂nanotubes after ALIM treatment promote natural apatite formation significantlyin a simulated body fluid (SBF). Such TiO₂ nanotube arrays with ALIMtreatment, are useful as a well-adhered bioactive surface layer on Ti implantmetals for orthopaedic and dental implants.

Key words: TiO₂nanotubes, ALIM, fill, biological apatite

中图分类号:

O646
O614

俞佳,肖秀峰, 梁建鹤,刘榕芳, 王春燕,毛丹. 交替循环浸泡在TiO₂纳米管管内填充类骨磷灰石[J]. 无机材料学报, 2011, 26(1): 78-84.

YU Jia,XIAO Xiu-Feng, LIANG Jian-He,LIU Rong-Fang, WANG Chun-Yan,MAO Dan. Filling TiO₂Nanotubes with Biological Apatite by Alternative Loop Immersion Method[J]. Journal of Inorganic Materials, 2011, 26(1): 78-84.

参考文献

[1] Long M, Rack H J. Titanium alloys in total joint replacement. Biomaterials, 1998, 19(18): 1621-1639.
[2] Kokubo T, Takadama H. How useful is SBF in predicting <>in vivobone bioactivity. Biomaterials, 2006,27(15): 2907-2915.
[3] Kar A, Raja K S, Misra M. Electrodeposition of hydroxyapatite ontonanotubular TiO₂ for implant applications. Surf. & Coat. Tech., 2006, 201(6):3723-3731.
[4] Ravelingien M, Hervent A S, Mullens S, et al. Influence of surface topographyand pore architecture of alkali-treated titanium on in vitro apatite deposition. Appl.Surf. Sci., 2010, 256(11): 3693-3697.
[5] Kim D Y, Kim M Y, Kim H E, etal. Formation of hydroxyapatite within porous TiO₂ layer by micro-arcoxidation coupled with electrophoretic deposition. Acta Biomaterialia, 2009, 5(6):2196-2205.
[6] Lee J H, Kim H E, Koh Y H. Highly porous titanium (Ti) scaffoldswith bioactive microporous hydroxyapatite/TiO₂ hybrid coating layer.Mater. Lett., 2009, 63(23): 1995-1998.
[7] Liu XY, Chu P K, Ding C X. Surface modification of titanium, titanium alloys, andrelated materials for biochemical applications. Mater. Sci. Eng. R, 2004, 47(3/4):49-121.
[8] Yang B,Uchida M, Kim H M, et al. Preparationof bioactive titanium metal viaanodic oxidation treatment. Biomaterials,2004, 25(6): 1003-1010.
[9] Song W H, Jun Y K, Han Y, et al. Biomimetic apatite coatings on micro-arc oxidized titania. Biomaterials, 2004, 25(17): 3341-3349.
[10]Kodama A, Bauer S, Komatsu A, et al. Bioactivation of titaniumsurfaces using coatings of TiO₂ nanotubes rapidly pre-loaded withsynthetic hydroxyapatite. ActaBiomaterialia, 2009, 5(6): 2322-2330.
[11]Hench L L. Bioceramics: from concept to clinic.J. Am. Ceram. Soc., 1991, 74(7): 1487-1510.
[12]Gong D W, Grimes C A, Varghese OK, et al. Titanium oxide nanotube arraysprepared by anodie oxidation. J. Mater. Res., 2001, 16(12): 3331-3334.
[13] Macak J M, Tsuchiya H, Ghicov A, et al. TiO₂ nanotubes: self-organizedelectrochemical formation, properties and applications. Cur. Opi. Solid. State. Mater. Sci., 2007, 11(1/2): 3-18.
[14]Song Y, Schmidt-Stein F, Bauer S, et al. Amphiphilic TiO₂ nanotubearrays: an actively controllable drug delivery system. J. Am. Chem. Soc., 2009, 131(12):4230-4232.
[15]KokuboT, Kushitani H, Sakka S, <>et al. Solution able to reproduce in vivo surface-structure changes inbioactive glass-ceramics A-W3. J. Biomed.Mater. Res., 1990, 24(6):721-734.
[16]梁建鹤, 肖秀峰, 刘榕芳, 等(LIANG Jian-He, etal). 宽电压范围下阳极氧化制备TiO₂纳米管阵列及其热稳定性. 无机化学学报(Chinese Journal of Inorganic Chemistry),2010, 37(1): 112-119.
[17] 黄平, 徐可为, 憨勇(HUANG Ping, <>et al). 富含钙磷的多孔氧化钛膜及其生物活化机理. 硅酸盐学报(Journal of the Chinese Ceramic Society),2004, 32(12): 1449-1454.
[18] Shi D L. Introduction to Biomaterials. 北京: 清华大学出版社, 2005: 14-25.
[19] Wei M, Kim H M, Kokubo T, etal. Optimising the bioactivity of alkaline-treated titanium alloy. Mater. Sci. Eng. C,2002, 20(1/2): 125-134.
[20] Oh S H, Finones R R, Daraio C, et al. Growth ofnano-scale hydroxyapatite using chemically treated titanium oxide nanotubes. Biomaterials. 2005,26(24): 4938-4943.
[21] Andrei G, Hiroaki T, Macak J M, etal. Titanium oxide nanotubes prepared in phosphate electrolytes. Electrochemistry Communications, 2005, 7(5): 505-509
[22] Bauer S, Kleber S, Schmuki P. TiO₂ nanotubes: tailoringthe geometry in H₃PO₄/HF electrolytes. Electrochemistry Communications, 2006, 8(8): 1321-1325
[23]Tsuchiya H, Macak J M, Muller L, et al. Hydroxyapatite growth on anodicTiO₂ nanotubes. J. Biomed. Mater. Res. Part. A, 2006, 77(3): 534-541.
[24] Kunze J, Müller L, Macak J M, et al. Time-dependentgrowth of biomimetic apatite on anodic TiO₂ nanotubes. Electrochimica Acta, 2008, 53(23): 6995-7003.
[25]Jonasova L, Müller F A,Helebrant A, <>et al. Biomimetic apatite formation on chemically treated titanium.Biomaterials, 2004, 25(7/8): 1187-1194.

交替循环浸泡在TiO₂纳米管管内填充类骨磷灰石

Filling TiO₂Nanotubes with Biological Apatite by Alternative Loop Immersion Method

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	吴秋琴, 姚奋发, 金传洪, 郑遗凡. 碳纳米管内填充生长超细一维亚化学计量比氧化钨纳米线[J]. 无机材料学报, 2022, 37(4): 413-419.
[2]	张维维, 陆晨, 应国兵, 张建峰, 江莞. AlN表面处理及级配填充对覆铜板绝缘层性能的影响规律与机制研究[J]. 无机材料学报, 2021, 36(8): 847-855.
[3]	金朝, 陈其汉, 郑梦佳, 赵鹏, 李倩, 崔小强. Au纳米粒子/双层TiO₂周期结构的制备及其对乙醇的电催化性质[J]. 无机材料学报, 2016, 31(3): 241-247.
[4]	姚铮, 仇鹏飞, 李小亚, 陈立东. n型填充方钴矿热电材料的快速制备研究[J]. 无机材料学报, 2016, 31(12): 1375-1382.
[5]	罗华明, 刘志勇, 白传易, 鲁玉明, 蔡传兵. 基于二氧化钛纳米管的染料敏化电池光阳极研究[J]. 无机材料学报, 2013, 28(5): 521-526.
[6]	吴汀, 柏胜强, 史迅, 陈立东. 高填充量Ba_xEu_yCo₄Sb₁₂方钴矿热电性能研究[J]. 无机材料学报, 2013, 28(2): 224-228.
[7]	赵丽, 范佳杰, 李静, 戴国田, 王世敏. ZnO/TiO₂纳米管晶膜电极的制备及光电性能[J]. 无机材料学报, 2012, 27(6): 585-590.
[8]	金冲, 张卫国, 姚素薇, 王宏智. 热处理工艺对TiO₂纳米管阵列结构及其光电性能的影响[J]. 无机材料学报, 2012, 27(1): 54-58.
[9]	于榕, 冯波, 汪建新, 鲁雄, 屈树新, 翁杰. TiO₂纳米管表面蛋白质-羟基磷灰石复合涂层及其结合强度[J]. 无机材料学报, 2011, 26(9): 987-992.
[10]	池永庆, 陈旭, 张忠林, 刘世斌, 段东红, 郝晓刚, 孙彦平. 模板法Li₄Ti₅O₁₂纳米线阵列的制备及其机理分析[J]. 无机材料学报, 2011, 26(5): 529-534.
[11]	陈秀琴, 张兴旺, 雷乐成. F掺杂 TiO₂ 纳米管阵列的可见光催化活性和电子结构[J]. 无机材料学报, 2011, 26(4): 369-374.
[12]	崔强, 冯波, 陈伟, 汪建新, 鲁雄, 翁杰. 形貌对锐钛矿型TiO₂纳米管薄膜光催化性能的影响[J]. 无机材料学报, 2010, 25(9): 916-920.
[13]	魏平, 董春垒, 赵文俞, 张清杰. 纳米SiO₂包覆提高填充方钴矿热电材料热稳定性[J]. 无机材料学报, 2010, 25(6): 577-582.
[14]	李荐, 罗佳, 彭振文, 郭欣. 不同阳极氧化条件下TiO₂纳米管阵列的制备及表征[J]. 无机材料学报, 2010, 25(5): 490-494.
[15]	罗军，廖斌，陈一鸣，刘安东，刘培生. TiO₂纳米管负载纳米金的制备及其在紫外光下的光电性能[J]. 无机材料学报, 2010, 25(5): 557-560.