头孢拉定/蒙脱石插层化合物的制备

doi:10.3724/SP.J.1077.2012.00655

无机材料学报 ›› 2012, Vol. 27 ›› Issue (6): 655-659.DOI: 10.3724/SP.J.1077.2012.00655 CSTR: 32189.14.SP.J.1077.2012.00655

头孢拉定/蒙脱石插层化合物的制备

赵彦钊¹, 郭文姬¹, 王兰²

(陕西科技大学 1. 材料科学与工程学院; 2. 生命科学与工程学院, 西安 710021)

收稿日期:2011-07-15 修回日期:2011-10-17 出版日期:2012-06-20 网络出版日期:2012-05-07

Preparation of Cefradine/ Montmorillonite Intercalation Compound

ZHAO Yan-Zhao¹, GUO Wen-Ji¹, WANG Lan²

(1. School of Materials Science & Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China; 2. College of Life Science & Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China)

Received:2011-07-15 Revised:2011-10-17 Published:2012-06-20 Online:2012-05-07

摘要/Abstract

摘要： 采用医药级蒙脱石和钠基蒙脱石作载体材料, 通过溶液插层法制备了头孢拉定/蒙脱石插层化合物. 采用紫外分光光度法定量计算其载药量, 采用X射线衍射和傅立叶红外光谱测试定性分析其结构, 研究其层间结构变化情况. 结果表明, 头孢拉定与蒙脱石发生插层反应主要是由于离子交换作用, 简单的物理混合不能使二者发生插层反应. 钠化后的医药级蒙脱石有较好的离子交换特性, 易于发生插层反应. 医药级蒙脱石和头孢拉定在水中进行插层反应后, 蒙脱石的层间距减小; 而钠基蒙脱石和医药级蒙脱石钠化改性后制备的插层化合物层间距均增大.

关键词: 蒙脱石, 头孢拉定, 离子交换性, 溶液插层法

Abstract: The cefradine/montmorillonite compounds were prepared by pharmaceutical montmorillonite (MMT) and sodium-montmorillonite (Na-MMT) by the method of solution intercalation. The drug load was quantitatively measured by UV spectrophotometry. The structures of compounds were determined by X-Ray Diffraction (XRD) and Fourier transformed infrared (FT-IR) spectroscope. The results show that cefradine can be intercalated into MMT mainly due to ion exchange, which cannot intercalate into MMT by mechanically mixing. Pharmaceutical MMT shows better ion exchange property after sodium modification, which is easily intercalated. The basal spacing of pharmaceutical MMT changes little after intercalation in water, however, the basal spacing of Na-MMT and pharmaceutical MMT after sodium modification increase.

Key words: montmorillonite, cefradine, ion exchange, solution intercalation

中图分类号:

TQ174

赵彦钊, 郭文姬, 王兰. 头孢拉定/蒙脱石插层化合物的制备[J]. 无机材料学报, 2012, 27(6): 655-659.

ZHAO Yan-Zhao, GUO Wen-Ji, WANG Lan. Preparation of Cefradine/ Montmorillonite Intercalation Compound[J]. Journal of Inorganic Materials, 2012, 27(6): 655-659.

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头孢拉定/蒙脱石插层化合物的制备

Preparation of Cefradine/ Montmorillonite Intercalation Compound

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