聚烯丙基氯化铵调控下多孔羟基磷灰石微球的合成及作为药物载体的应用研究
收稿日期: 2017-01-18
修回日期: 2017-03-13
网络出版日期: 2017-10-20
基金资助
国家自然科学基金(21571004);安徽省高等学校自然科学基金重点项目(KJ2015A084);National Natural Science Foundation of China (21571004);Natural Science Foundation of the Anhui Higher Education Institutions of China (KJ2015A084)
Porous Hydroxyapatite Microspheres Prepared by Using Poly (Allylamine Hydrochloride) and Its Application in Drug Delivery
Received date: 2017-01-18
Revised date: 2017-03-13
Online published: 2017-10-20
选用聚烯丙基氯化铵(PAH)作为晶体生长调节剂, 在水热条件下成功制备了多孔羟基磷灰石(Hydroxyapatite, HAP)中空微球。详细研究了反应时间和添加剂浓度等因素的影响: 150℃水热反应12 h, 控制PAH 浓度0.3~0.5 g/L, 可合成尺寸均匀、孔径密集的HAP中空微球。微球生长经历早期前驱体微结构、异相成核、相转化等不同阶段, 聚合物在各阶段都起到重要的调节作用。以典型的布洛芬(ibuprofen, IBU)作为模型药物, 研究微球的药物负载和脱附能力。结果显示: 多孔微球具有良好的药物负载和释放能力, 吸附量较好, 可达到413.65 mg/g。且药物具有较好的pH响应释放行为, 可作为pH敏感靶向药物载体应用到生物医学等领域。
马芳 , 崔名芳 , 朱建华 , 李雅丽 . 聚烯丙基氯化铵调控下多孔羟基磷灰石微球的合成及作为药物载体的应用研究[J]. 无机材料学报, 2017 , 32(11) : 1215 -1222 . DOI: 10.15541/jim20170041
Porous and hollow hydroxyapatite (HAP) microspheres were synthesized successfully in hydrothermal method utilizing poly(allylamine hydrochloride) (PAH) as the crystal growth regulator. Effects of reaction time and concentration of the polymer on the growth of final products were investigated. Uniform microspheres with dense pores can be synthesized by controlling the PAH concentration (0.3-0.5 g/L) after 12 h hydrothermal reaction at 150℃. Formation of hollow microspheres includes different stages of early precursor microstructures, heterogeneous nucleation and phase transformations. At different stages, the cationic polyelectrolyte PAH plays an important role in regulating growth of hollow microspheres. Ibuprofen (IBU) was chosen as a typical model drug to study the drug loading and the desorption ability. The results show that porous and hollow microspheres have relatively high drug loading capacity (413.65 mg/g). Drug release of the microspheres is favorably pH-responsive, which may have close relationship with the surface properties of HAP nanorods. Date from this study suggest that the porous microspheres will have potential application as the targeted-drug carrier in the biomedicine field.
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