高级检索
无机材料学报

无机材料学报 >

2010 , Vol. 25 >Issue 1: 53 - 57

DOI: https://doi.org/10.3724/SP.J.1077.2010.00053

研究论文

硼酸盐玻璃转化制备中空羟基磷灰石微球的研究

  • 姚爱华 ,
  • 艾凡荣 ,
  • 刘 欣 ,
  • 王德平 ,
  • 黄文旵
展开
  • (同济大学 1. 材料科学与工程学院; 2. 先进土木工程材料教育部重点实验室, 上海 200092)

收稿日期: 2009-04-08

  修回日期: 2009-06-05

  网络出版日期: 2010-01-24

收起

Study on Hollow Hydroxyapaptite Microspheres Prepared by a Borate Glass Conversion Process

  • YAO Ai-Hua ,
  • AI Fan-Rong ,
  • LIU Xin ,
  • WANG De-Ping ,
  • HUANG Wen-Hai
Expand
  • (1. School of Materials Science and Engineering, Tongji University, Shanghai 200092, China; 2. Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, Tongji University, Shanghai 200092, China)

Received date: 2009-04-08

  Revised date: 2009-06-05

  Online published: 2010-01-24

Fold

摘要

利用锂钙硼玻璃在磷酸盐溶液中的原位转化反应制备表面多孔且中空的羟基磷灰石（HAP）微球, 通过XRD、SEM和BET对微球的物相组成、形貌和球壳的孔结构进行了表征. 结果表明, 微球具有良好的中空结构, 600℃热处理后, 微球球壳完全由HAP晶体组成, 并显示出一定的机械强度（单个微球的抗压强度达到(2.1±0.6)MPa）, 球壳的气孔率为85%, 平均孔径60nm. 此外, 对中空HAP微球的形成机理进行了分析. 在磷酸盐溶液中, 玻璃表面原位生成Ca-P-OH水化物, 并在玻璃表面原来Ca2+的位置沉积下来, 形成微球壳, 而由Li+和B3+占据的位置, 因其溶出形成孔隙. 这样的结构将使之成为贮库型药物释放系统的载体.

关键词： 羟基磷灰石; 中空微球; 硼酸盐玻璃; 药物载体

本文引用格式

姚爱华 , 艾凡荣 , 刘 欣 , 王德平 , 黄文旵 . 硼酸盐玻璃转化制备中空羟基磷灰石微球的研究[J]. 无机材料学报, 2010 , 25(1) : 53 -57 . DOI: 10.3724/SP.J.1077.2010.00053

Abstract

Hollow hydroxappatite (HAP) microspheres consisting of a hollow core and a porous shell were prepared by a Li-Ca-B glass conversion process. The phase composition, morphology and pore structure on the shell wall were investigated using XRD, SEM and BET. The results showed that the asprepared microspheres possessed good internal hollow structure. The shell wall of the microsphere was made up of HAP crystals fully. After heattreated at 600℃ for 2h, the compressive strength of the microsphere was determined to be (2.1±0.6)MPa, and the porosity and pore size of the shell wall were 85% and 60nm, respectively. Furthermore, the formation mechanism of the hollow HAP microsphere was also suggested. In phosphate solution, Ca-P-OH hydrate was in-situ formed on the surface of the glass and precipitated in the position initially occupied by Ca2+, while the pores were formed in the position initially occupied by Li+ and B3+. These hollow HAP microspheres may be useful for drug delivery.

Key words： hydroxyapatite; hollow microsphere; borate glass; drug delivery

参考文献

［1］刘桂霞, 洪广言, 王进贤, 等. 化学通报, 2006, 69(10): 947-952.
［2］Caruso F, Caruso R A, Mohwald H. Science, 1998, 282(5391): 1111-1114.
［3］Breen M L, Dinsmore A D, Pinketal R H. Langmuir, 2001, 17(3): 903-907.
［4］Makuta T, Takada S, Daiguji H, et al. Mater. Lett., 2009, 63(8): 703-705.
［5］Ren N, Wang B, Yang Y, et al. Chem. Mater., 2005, 17(10): 2582-2587.
［6］Zhang Y X, Li G H, Zhang L D. Inorg. Chem. Commun., 2004, 7(3): 344-346.
［7］Berling J, Blmer J, Kümmel R. Chem. Eng. Technol., 2004, 27(8): 829-830.
［8］Hu J S, Guo Y G, Liang H P, et al. J. Phys. Chem. B, 2004, 108(28): 9734-9738.
［9］Nakashima T, Kimizuka N. J. Am. Chem. Soc., 2003, 125(21): 6386-6387.
［10］闫共芹, 官建国, 王 维(YAN Gong-Qin, et al). 物理化学学报(Acta PhysioChimica Sinica), 2007, 23(12): 1958-1962.
［11］蒋锡华, 曹洁明, 郑明波, 等(JIANG Xi-Hua). 物理化学学报(Acta PhysioChimica Sinica), 2007, 23(8): 1281-1284.
［12］李延报, 李东旭, 翁文剑 (LI Yan-Bao, et al). 无机材料学报 (Journal of Inorganic Materials), 2007, 22(5): 775-782.
［13］Hench L L. Science, 1980, 208(4446): 826-832.
［14］黄文旵, 王 青, 王德平. 同济大学学报（自然科学版）, 2005, 33(1): 88-92.
［15］Wang Q, Huang W H, Wang D P, et al. J. Mater. Sci.: Mater. Med., 2006, 17(7): 641-646.
［16］Huang W H, Rahaman M N, Day D E, et al. J. Mater. Sci.: Mater. Med., 2009, 20(1): 123-129.
［17］Pernice P, Esposito S, Aronne A, et al. J. NonCrystal. Solids, 1999, 258(1/2/3): 1-10.
Options
文章导航

/

〈 〉