研制了用于软骨的组织工程的HA/PU多孔支架材料, 采用气体发泡法制备了三维贯通的多孔HA/PU支架材料, 通过XRD、IR对其结构组成进行了分析, 用DSC测量了玻璃化转变温度, 用SEM观察了微观形貌和孔径尺寸, 并计算了孔隙大小和孔隙率的分布. 通过燃烧试验分析了HA/PU复合材料中HA的百分含量, 并对力学性能进行了评估. 结果表明, 多孔HA/PU复合支架材料, 其大小孔道相互贯通, 孔径范围在100~800μm, 大孔中含有微孔, 孔隙率可达到78%~80%, HA含量达到30wt%, 力学强度达到271kPa. 多孔HA/PU复合材料具有一定的弹性, 是一类性能很好的可望用于软骨修复的支架材料.
Three dimensional and interconnective porous HA/PU scaffold material was prepared for tissue engineering by a gas foaming method, and its structure and composition were analyzed by XRD,IR. Glass transition temperature was measured by DSC curve. The micromorphology and pore size were observed and the pore sizes and distribution were calculated. The content of HA in PU/HA composite and mechanical performance were tested. The results indicate that porous HA/PU composite scaffold has good interconnectivity with typical pore sizes ranging from 100μm to 800μm. Its porosity can reach 78%--80%.When the content of HA in HA/PU composite is 30wt%, the mechanical strength of the HA/PU composite is 271kPa. The porous HA/PU scaffold has good elasticity which is a good potential material for soft bone repair scaffold.
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