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2009 , Vol. 24 >Issue 5: 882 - 888

DOI: https://doi.org/10.3724/SP.j.1077.2009.00882

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骨与牙釉质组织的生物矿化及磷酸钙材料仿生合成研究进展

  • 杜 昶 ,
  • 王迎军
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  • （华南理工大学 1. 生物医学工程研究院； 2. 特种功能材料教育部重点实验室； 3. 材料科学与工程学院， 广州 510641）

收稿日期: 2009-04-01

  修回日期: 2009-04-27

  网络出版日期: 2009-09-20

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Progress in the Biomineralization Study of Bone and Enamel and Biomimetic Synthesis of Calcium Phosphate

  • DU Chang ,
  • WANG Ying-Jun
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  • (1. Biomedical Engineering Institute, South China University of Technology, Guangzhou 510641, China; 2. Key Laboratory of Specially Functional Materials, Ministry of Education, Guangzhou 510641, China; 3. College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China)

Received date: 2009-04-01

  Revised date: 2009-04-27

  Online published: 2009-09-20

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摘要

骨和牙釉是典型的有机基质介导生成的生物矿化材料，其中的矿物相都属于以磷灰石为主的钙磷酸盐系统，但有机基质的不同使得晶体尺寸、形貌及排列方式迥异.本文综述了有关骨和牙釉组织的生物矿化研究，重点探讨对这些天然生物矿化组织的分级结构、基质蛋白的自组装及调控矿化机理的认识.在此基础上，磷酸钙材料的仿生合成以期应用于硬组织的缺损修复或再生医学也是目前的重要研究内容.

关键词： 骨; 牙釉; 生物矿化; 仿生合成

本文引用格式

杜 昶 , 王迎军 . 骨与牙釉质组织的生物矿化及磷酸钙材料仿生合成研究进展[J]. 无机材料学报, 2009 , 24(5) : 882 -888 . DOI: 10.3724/SP.j.1077.2009.00882

Abstract

Bone and enamel are typical biomineralized materials through organic matrix-mediated processes. The mineral phase in bone and enamel is mainly apatitic calcium phosphate, but their size, morphology and organization are depending on the different composition and property of the matrix in two tissues. This paper reviews the progress of biomineralization study of bone and enamel, in particular the current understanding on the hierarchical structure of the tissues, the self-assembly of matrix proteins and the mechanism of matrixmediated mineralization. The biomimetic synthesis of calcium phosphate for hard tissues repair and regeneration is also discussed.

Key words： bone; enamel; biomineralization; biomimetic synthesis

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